Our primary objective was to investigate a biomarker driven model for the interrelationships
between vascular disease pathology, amyloid pathology, and longitudinal cognitive decline …

Objective To investigate the multifactorial processes underlying cognitive aging based on
the hypothesis that multiple causal pathways and mechanisms (amyloid, vascular, and …

The present study evaluated cerebrovascular disease (CVD), β-amyloid (Aβ), and cognition
in clinically normal elderly adults. Fifty-four participants underwent magnetic resonance …

Importance Identifying asymptomatic individuals at high risk of impending cognitive decline
because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk …

The objective of this study was to examine whether the effects of age-related
neuropathologies on cognition change over time. Participants were 1096 deceased persons …

Objective The pathologic indices of Alzheimer disease, cerebrovascular disease, and Lewy
body disease accumulate in the brains of older persons with and without dementia, but the …

Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in
subjects with cognitive impairment. However, the relationship between CVD, amyloid …

Objective Recent availability of amyloid and tau positron emission tomography (PET) has
provided us with a unique opportunity to measure the association of systemic vascular …

Objective: Although it is now widely accepted that dementia has a long preclinical phase
during which neuropathology accumulates and cognition declines, little is known about the …

Objective To investigate the associations between age, vascular health, and Alzheimer
disease (AD) imaging biomarkers in an elderly sample. Methods We identified 430 …