Objective To determine whether amyloid deposition is associated with impaired
neuropsychological (NP) performance and whether cognitive reserve (CR) modifies this …

Objective: Neurodegenerative and cerebrovascular conditions are common in old age and
are associated with cognitive decline. However, considerable heterogeneity remains in …

Objectives: To explore whether more cognitive complaints are associated with previous or
future cognitive decline. Design: Longitudinal; epidemiology vascular aging study. Setting …

To determine the relationship between amyloid burden and neural function in healthy adults
at risk for Alzheimer's Disease (AD), we used multimodal imaging with [C-11] Pittsburgh …

Recent studies suggest that dementia in the most elderly (90 years of age and above) is only
modestly related to Alzheimer's disease pathology. This raises the possibility that other, as …

Importance Midlife vascular risk factors have been associated with late-life dementia.
Whether these risk factors directly contribute to brain amyloid deposition is less well …

Objective: To test the hypothesis that cognitive activity across the life span is related to late-
life cognitive decline not linked to common neuropathologic disorders. Methods: On …

Background and Purpose—Brain atrophy, cortical infarction, and subcortical ischemic
vasculopathy have all been associated with cognitive dysfunction. The interrelationships …

Objective: To investigate the vascular contribution to longitudinal changes in Alzheimer
disease (AD) biomarkers. Methods: The Alzheimer's Disease Neuroimaging Initiative is a …

Objective To investigate predictors of performance on a range of cognitive measures
including the Preclinical Alzheimer Cognitive Composite (PACC) and test for associations …