Objective To study the relationship between subjective cognition and the neuropathological
hallmark of Alzheimer disease (AD), amyloid-β (Aβ) deposition, using carbon 11–labeled …

Background and purpose: Age related white matter changes (ARWMC) are frequent in non-
demented old subjects and are associated with impaired cognitive function. Our aim was to …

Background Vascular factors including medical history (heart disease, stroke, diabetes, and
hypertension), smoking, and prediagnosis blood lipid measurements (cholesterol: total, high …

Objective Subjective cognitive complaints in otherwise normal aging are common but may
be associated with preclinical Alzheimer disease in some individuals. Little is known about …

The MRC Cognitive Function and Ageing Study (CFAS) is a prospective longitudinal study of
a population-based cohort of elderly people in six UK sites, evaluated using psychometric …

Objective: To determine whether a high prevalence (55%) of Aβ deposition in a cohort of
individuals remaining dementia-free into their 9th and 10th decades is associated with …

BACKGROUND: Progressive intraindividual decline in memory and cognition is
characteristic of dementia and may be useful in detecting very early Alzheimer's disease …

We recently demonstrated that the frequencies of biomarker groups defined by the presence
or absence of both amyloidosis (A+) and neurodegeneration (N+) changed dramatically by …

Objectives Amyloid‐beta (Aβ) and tau pathologies are commonly observed among clinically
normal older individuals at postmortem and can now be detected with in vivo neuroimaging …

We examined the interaction of brain atrophy and white matter lesions (WML) with cognitive
functioning in 605 patients (mean age, 58±10; 76% men) with atherosclerotic disease from …