An augmented synthesis of tetrahydroisoquinolines, such as salsolinol (SAL) or an
increased N-methylation of these compounds has been addressed by various investigators …

Various investigators address an augmented synthesis of tetrahydroisoquinolines, such as
salsolinol (SAL), or an increased N-methylation of these compounds as putative …

Summary N-Methyl (R) salsolinol, an endogenous neurotoxin, has been proposed to be
closely involved in the pathogenesis of Parkinson's disease. The selective toxicity to …

Summary A dopamine-derived 1 (R), 2 (N)-dimethyl-6, 7-dihydroxy-1, 2, 3, 4-
tetrahydrosioquinoline [N-methyl-(R) salsolinol] was found to occur enantio-selectively in …

The concentration of (R)‐N‐methylsalsolinol, which is a dopamine‐derived neurotoxin
selective to dopamine neurons and induces parkinsonism in rats, was found to be increased …

The pathogenesis of Parkinson's disease is still an enigma. As an endogenous MPTP-like
neurotoxin, N-methyl (R) salsolinol was proved to induce parkinsonism in rats and apoptosis …

Dopamine-derived 1-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline (salsolinol, Sal)
and related compounds were examined for their selective neurotoxicity to dopamine …

A dopamine-derived alkaloid, N-methyl-(R)-salsolinol [NM (R) Sal], enantioselectively
occurs in human brains and accumulates in the nigrostriatal system. It increases in the …

Abstract Background: Parkinson disease (PD), a progressive neurodegenerative disease,
affects at least 1% of population above the age of 65. Although the specific etiology of PD …

In the human brain, isoquinolines are synthesized from catecholamines, β-
phenylethylamine, and indoleamines, and their involvement in the pathogenesis of …