Adaptive immune responses mediated by T cells and B cells are crucial for protective
immunity against pathogens and tumors. Differentiation and function of immune cells require …

Metabolism is a core process underlying essentially all biological functions. The integration
of metabolism with immunity, known as immunometabolism, is at the forefront of immunology …

Choices have consequences. Immune cells survey and migrate throughout the body and
sometimes take residence in niche environments with distinct communities of cells …

The immune system defends against pathogens and maintains tissue homeostasis for the
life of the organism. These diverse functions are bioenergetically expensive, requiring …

The immune response requires major changes to metabolic processes, and indeed, energy
metabolism and functional activation are fully integrated in immune cells to determine their …

Recent studies indicate that cellular metabolism plays a key role in supporting immune cell
maintenance and development. Here, we review how metabolism guides immune cell …

Immune cells are highly dynamic in terms of their growth, proliferation, and effector functions
as they respond to immunological challenges. Different immune cells can adopt distinct …

Background Naïve lymphocytes circulate in the body in a resting state, but upon recognition
of foreign antigen and receipt of proper costimulatory signals, these cells become activated …

The maintenance of organismal homeostasis requires partitioning and transport of
biochemical molecules between organ systems, their composite cells, and subcellular …

Renewed interest in immune cell metabolism has led to the emergence of a research field
aimed at studying the importance of metabolic processes for an effective immune response …