Background The need for early antibiotics in the intensive care unit (ICU) is often balanced
against the goal of antibiotic stewardship. Long-course antibiotics increase the burden of …

Introduction Altered pharmacokinetics (PK) in critically ill patients can result in insufficient
serum β-lactam concentrations when standard dosages are administered. Previous studies …

Background To be able to diagnose and treat sepsis better it is important not only to improve
the knowledge about definitions and pathophysiology, but also to gain more insight into …

Background The Surviving Sepsis 6-hour bundle [1] was created to promote effective
identification and management of patients with severe sepsis and septic shock. Efficient and …

Introduction Severe sepsis is associated with high levels of morbidity and mortality, placing a
high burden on healthcare resources. We aimed to study outcomes in the five years after …

Background The present study was performed to investigate the impacts of type 2 diabetes
mellitus (T2DM) on severe community-acquired pneumonia (SCAP) and to develop a novel …

Methods A prospective cohort study involving 75 ICUs all over Brazil was performed. All
patients who were admitted or developed sepsis during a 1-month period were enrolled and …

Methods An observational, retrospective study of patients with severe CAP admitted to the
ICU between January 2008 and September 2013. We analyzed clinical, epidemiological …

Introduction Sepsis and severe sepsis are asociated with high hospital mortality. Little is
known about the occurrence of sepsis in general hospital populations. The goal of the …

Introduction The aim of this study was to create a predictive score for yeast isolation in
patients with complicated non-postoperative intra-abdominal infections (CNPIAI) and to …