✓ A three-dimensional model has been developed in which C6 astrocytoma spheroids of
defined sizes are embedded into collagen type I gels. The authors have monitored cell …

Objective: The dynamic mechanisms underlying the three-dimensional invasive paradigm of
C 6 astrocytoma cells has been assessed. Methods: Spheroids of C 6 astrocytoma cells …

✓ Type IV collagen is a major protein component of the vascular basement membrane and
its degradation is crucial to the initiation of tumor-associated angiogenesis. The authors …

Abstract A BETTER UNDERSTANDING of the influences of specific extracellular substrates,
including proteins, glycosaminoglycans, and parenchymal cells, on the invasive behavior of …

Tumor growth is dependent on the ability of neoplastic cells to induce angiogenesis.
Remodelling of blood vessels requires reconstruction of the collagen (type IV) and non …

Objective: The orthotopic C6 glioma spheroid implantation model has been used to examine
factors of neoangiogenesis, growth factor release, and protease expression as well the …

An experimental model of malignant glioma growth involving implantation of spheroids into
a gel matrix of collagen type I has been developed. This model has been used to …

Individual astrocytoma cells expressing a cytoplasmic form of pl85 c-neu migrated along
basement membrane lined surfaces after xenografing fresh low or high grade human …

OBJECTIVE: The major morbidity of glioma lies in its infiltrative growth. One of the major
patterns of this invasive growth is the formation of Scherer's secondary structures associated …

Abstract INVADING GLIOMA CELLS seem to follow distinct anatomic structures within the
central nervous system. Tumor cell dissemination may occur along structures, such as the …