In order for cancer cells to successfully colonize a metastatic site, they must detach from the
primary tumor using extracellular matrix-degrading proteases, intravasate and survive in the …

The multi-step process of the emigration of cells from the blood stream through the vascular
endothelium into the tissue has been termed extravasation. The extravasation of leukocytes …

During metastasis, cancer cells disseminate to other parts of the body by entering the
bloodstream in a process that is called intravasation. They then extravasate at metastatic …

Most metastasizing tumor cells reach distant sites by entering the circulatory system. Within
the bloodstream, they are exposed to severe stress due to loss of adhesion to extracellular …

Most cancer patients die as a result of metastasis, thus it is important to understand the
molecular mechanisms of dissemination, including intra-and extravasation. Although the …

In this report, we challenge a common perception that tumor embolism is a size-limited event
of mechanical arrest, occurring in the first capillary bed encountered by blood-borne …

Metastasis is the end product of a multistep process where cancer cells disseminate and
home themselves in distant organs. Tumor cell extravasation is a rare, inefficient and …

Under a variety of (patho) physiological conditions, leukocytes will leave the bloodstream by
crossing the endothelial monolayer that lines the vessels and migrate into the underlying …

The haematogenous phase of cancer metastasis facilitates the transport of metastatic cells
within the blood and incorporates a sequence of interactions between circulating …

Metastasis is the leading cause of cancer mortality. The metastatic cascade represents a
multi-step process which includes local tumor cell invasion, entry into the vasculature …