Gene therapy, siRNA, and therapeutic aptamers attract great interest owing to their versatility
to treat a wide range of diseases and their potential high selectivity. Unfortunately …

The use of synthetic oligonucleotides as possible drugs for human therapy is usually
hampered by their low in vivo stability and capacity to achieve high concentrations at their …

This paper presents our most recent investigations on the effect of a soluble, inert polymer
as a conjugating agent for synthetic oligonucleotides. In particular, we studied in detail the …

Oligonucleotide-based agents are versatile biomolecules that modulate gene expression.
The last decade has seen the emergence of oligonucleotide-based tools for biochemical …

The preparation of diene-modified oligonucleotides as well as their properties and further
derivatization are described. Self-complementary oligonucleotides containing a diene …

A procedure has been developed for the preparation of peptide‐PEG‐oligonucleotide
conjugates: the two sequences were synthesized at the extremities of the same commercial …

The use of DNA and RNA oligonucleotides for therapeutic and diagnostic purposes has
created great interest in methods of enhancing their stability and delivery. One promising …

Oligonucleotide-based agents have the potential to treat or cure almost any disease, and
are one of the key therapeutic drug classes of the future. Bioconjugated oligonucleotides, a …

A novel method for the preparation of oligonucleotides conjugated with nucleophilic ligands
is described. A new phosphoramidite building block derived from N-chloroacetyl-6 …

Short synthetic oligonucleotides are finding wide variety of applications in area of genomics
and medicinal chemistry. Since the isolation of nucleic acids to the mapping of human …