The ionotropic glutamate receptor NMDA is allosterically modulated by glycine, a coagonist,
its presence is an absolute requirement for receptor activation. The transport of glycine in …

The recent discovery of glycine transporters in both the CNS and the periphery suggests that
the glycine transporter may play a critical role in NMDA receptor function by modulating …

Glycine has important neurotransmitter functions at inhibitory and excitatory synapses in the
vertebrate central nervous system. The effective synaptic concentrations of glycine are …

Glycine acts as an inhibitory neurotransmitter at glycine receptor (GlyR)-enriched synapses
and as an obligatory co-agonist at the N-methyl-D-aspartate (NMDA) receptor, where it …

The type 1 glycine transporter plays an important in regulating homeostatic glycine levels in
the brain that are relevant to the activation of the NMDA receptor by the excitatory …

Introduction. Glycine is one of the major inhibitory neurotransmitters in the spinal cord and
brain stem of vertebrates. 1 The inhibitory actions of glycine are mediated by the strychnine …

In the central nervous system, glutamate is essential for a proper synaptic communication in
neuronal networks supporting critical behavioral activities such as learning and memory …

The hypofunction hypothesis of glutamatergic neurotransmission via N-methyl-D-aspartate
(NMDA) receptors in the pathophysiology of schizophrenia suggests that increasing NMDA …

The simple amino acid glycine is implicated in both inhibitory and excitatory
neurotransmission in mammalian central nervous system, and it modulates excitatory …

Multiple lines of evidence indicate that hypofunction of glutamatergic neurotransmission via
N-methyl-D-aspartate (NMDA) receptors might be implicated in the pathophysiology of …