Profiling gene expression in single neurons using single-cell RNA-Seq is a powerful method
for understanding the molecular diversity of the nervous system. Profiling alternative splicing …

Although isoform diversity is acknowledged as a fundamental and pervasive aspect of gene
expression in higher eukaryotes, it is often omitted from single-cell studies due to …

Motivation: Gene expression and alternative splicing are strictly regulated processes that
shape brain development and determine the cellular identity of differentiated neural cell …

Alternative splicing is a key mechanism that shapes neuronal transcriptomes, helping to
define neuronal identity and modulate function. Here, we present an atlas of alternative …

Alternative splicing is widely acknowledged to be a crucial regulator of gene expression and
is a key contributor to both normal developmental processes and disease states. While cost …

Alternative splicing is a post-transcriptional regulatory mechanism producing multiple
distinct mRNA molecules from a single pre-mRNA. Alternative splicing has a prominent role …

Alternative splicing plays a major role in shaping tissue-specific transcriptomes. Among the
broad tissue types present in metazoans, the central nervous system contains some of the …

Although alternative splicing is a fundamental and pervasive aspect of gene expression in
higher eukaryotes, it is often omitted from single-cell studies due to quantification challenges …

The enormous cellular diversity in the mammalian brain, which is highly prototypical and
organized in a hierarchical manner, is dictated by cell-type–specific gene-regulatory …

The central nervous system has enormously complex cellular diversity with hundreds of
distinct cell types, yet alternative splicing features in single cells of important cell types at …