Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …

Cellular senescence is a complex and multistep biological process which cells can undergo
in response to different stresses. Referring to a highly stable cell cycle arrest, cellular …

An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …

Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

Much of the population is now faced with an enormous burden of age-associated chronic
diseases. Recent discoveries in geroscience indicate that healthspan in model organisms …

Cellular senescence is a primary aging process and tumor suppressive mechanism
characterized by irreversible growth arrest, apoptosis resistance, production of a …

The concept of geroscience is that since ageing is the greatest risk factor for many diseases
and conditions, targeting the ageing process itself will have the greatest impact on human …

Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in
response to cellular damage and stress. Senescent cells (SnCs) can develop a …

Cellular senescence is a highly stable cell cycle arrest that is elicited in response to different
stresses. By imposing a growth arrest, senescence limits the replication of old or damaged …

Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance,
and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated …