Cellular senescence in ageing: from mechanisms to therapeutic opportunities
R Di Micco, V Krizhanovsky, D Baker… - … reviews Molecular cell …, 2021 - nature.com
Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …
companies that target it to ameliorate a variety of human conditions. Eminently characterized …
Cellular senescence: mechanisms and therapeutic potential
Z Liao, HL Yeo, SW Wong, Y Zhao - Biomedicines, 2021 - mdpi.com
Cellular senescence is a complex and multistep biological process which cells can undergo
in response to different stresses. Referring to a highly stable cell cycle arrest, cellular …
in response to different stresses. Referring to a highly stable cell cycle arrest, cellular …
Cellular senescence: from mechanisms to current biomarkers and senotherapies
V Lucas, C Cavadas, CA Aveleira - Pharmacological Reviews, 2023 - ASPET
An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …
related diseases. In the last few decades, several studies have provided evidence of the …
[HTML][HTML] Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype
R Kumari, P Jat - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …
response to various intrinsic and extrinsic stimuli, as well as developmental signals …
Cellular senescence in age-related disorders
J Kaur, JN Farr - Translational Research, 2020 - Elsevier
Much of the population is now faced with an enormous burden of age-associated chronic
diseases. Recent discoveries in geroscience indicate that healthspan in model organisms …
diseases. Recent discoveries in geroscience indicate that healthspan in model organisms …
Reducing senescent cell burden in aging and disease
Cellular senescence is a primary aging process and tumor suppressive mechanism
characterized by irreversible growth arrest, apoptosis resistance, production of a …
characterized by irreversible growth arrest, apoptosis resistance, production of a …
Targeting cellular senescence with senotherapeutics: senolytics and senomorphics
The concept of geroscience is that since ageing is the greatest risk factor for many diseases
and conditions, targeting the ageing process itself will have the greatest impact on human …
and conditions, targeting the ageing process itself will have the greatest impact on human …
Cellular senescence: a key therapeutic target in aging and diseases
Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in
response to cellular damage and stress. Senescent cells (SnCs) can develop a …
response to cellular damage and stress. Senescent cells (SnCs) can develop a …
Mechanisms and functions of cellular senescence
N Herranz, J Gil - The Journal of clinical investigation, 2018 - Am Soc Clin Investig
Cellular senescence is a highly stable cell cycle arrest that is elicited in response to different
stresses. By imposing a growth arrest, senescence limits the replication of old or damaged …
stresses. By imposing a growth arrest, senescence limits the replication of old or damaged …
Cellular senescence: a translational perspective
JL Kirkland, T Tchkonia - EBioMedicine, 2017 - thelancet.com
Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance,
and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated …
and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated …