Increased lipid oxidation is generally observed in subjects with obesity and diabetes and
has been suggested to be responsible for the insulin resistance associated with these …

Context: Increased adipose tissue lipolytic activity is considered an important factor in the
pathogenesis of skeletal muscle insulin resistance associated with obesity. Objective: The …

Aims/hypothesis. To estimate non-esterified fatty acids kinetics in patients with Type II (non-
insulin-dependent) diabetes mellitus and obese subjects in the postabsorptive state and …

Background Elevated levels of circulating non-esterified fatty acids (NEFA) mediate many
adverse metabolic effects. In this work we aim to determine the impact of type 2 diabetes …

Whether sex differences in intramuscular triglyceride (IMTG) metabolism underlie sex
differences in the progression to diabetes are unknown. Therefore, the current study …

The aim of this project was to study the regulation of interstitial glycerol levels in muscle in
normal subjects, and to estimate interstitial muscle glycerol in obese subjects and patients …

OBJECTIVE We have previously shown that overnight fasted women have higher insulin-
stimulated whole body and leg glucose uptake despite a higher intramyocellular …

As an important energy reservoir, adipose tissue maintains lipid balance and regulates
energy metabolism. When the body requires energy, adipocytes provide fatty acids to …

Increased fat storage in adipose and non-adipose tissue (eg skeletal muscle) characterizes
the obese insulin resistant state. Disturbances in pathways of lipolysis may play a role in the …

The intracellular triglyceride content in skeletal muscle is increased in insulin-resistant states
such as obesity or high-fat feeding. It has been hypothesized that increased fatty acid …