To obtain further information on the regulation of lipolysis in vivo, the effect of increasing
sympathetic nerve activity via lower body negative pressure (LBNP,− 20 mm Hg) was …

Objective—Diabetic hypertriglyceridemia is thought to be primarily driven by increased
hepatic de novo lipogenesis. However, experiments in animal models indicated that insulin …

Obesity is a frequent cause of insulin resistance and poses a major risk for diabetes.
Abnormal fat deposition within skeletal muscle has been identified as a mechanism of …

The aim of this review is to summarize the mechanisms underlying insulin resistance in
morbid obesity. Glucose regulation by insulin depends on the suppression of endogenous …

Increased lipid availability reduces insulin-stimulated glucose disposal in skeletal muscle,
which is generally explained by fatty acid–mediated inhibition of insulin signaling. It remains …

Over the past decades, obesity and its metabolic co-morbidities such as type 2 diabetes
(T2D) developed to reach an endemic scale. However, the mechanisms leading to the …

To determine whether insulin regulation of lipolysis is abnormal in subjects with poorly
controlled insulin-dependent diabetes mellitus (IDDM), free-fatty acid flux ([1-14C] palmitate) …

Visceral fat accumulation relates to cardiovascular risk factors, but the underlying
mechanisms are not well understood. We investigated the role of visceral adipocyte …

Aims/hypothesis To test the hypothesis that adipose tissue lipolysis is enhanced in patients
with Type 2 diabetes mellitus, we examined the effect of exercise on regional adipose tissue …

Aims/hypothesis In the present study, we investigated the consequences of adipose tissue
lipolytic inhibition on skeletal muscle substrate use in type 2 diabetic patients. Materials and …