Aims/hypothesis The mechanisms for diet-induced intramyocellular lipid accumulation and
its association with insulin resistance remain contentious. In a detailed time-course study in …

Although the rate of fatty acid release from adipose tissue into the systemic circulation is very
high in most obese adults, some obese adults maintain relatively low rates of fatty acid …

In the transition from normal glucose tolerance (NGT) to type 2 diabetes mellitus (T2DM), the
role of β-cell dysfunction and peripheral insulin resistance (IR) is well established. However …

OBJECTIVE Changes in glucose metabolism occurring during counterregulation are, in part,
mediated by increased plasma free fatty acids (FFAs), as a result of hypoglycemia-activated …

Lipolytic responsiveness of subcutaneous and epididymal adipose tissue to norepinephrine
(NE) was measured by microdialysis before and during a euglycemic-hyperinsulinemic …

Context: Large fat cell size is linked to type 2 diabetes risk and may involve an enhanced
rate of adipocyte lipolysis causing elevated levels of fatty acids. Objective: Our objective was …

To determine whether the hepatic insulin resistance of obesity and type 2 diabetes is due to
impaired insulin-induced suppression of glycogenolysis as well as gluconeogenesis, 10 …

The aim of the present study was to measure whole body glucose uptake (M) and oxidation
rate by euglycaemic hyperinsulinaemic clamp and indirect calorimetry in 7 morbidly obese …

Skeletal muscle insulin resistance (IR) is typically severe in type 2 diabetes mellitus (DM).
However, the factors that account for interindividual differences in the severity of IR are not …

We present multiple findings on derangements in lipid metabolism in type 2 diabetes. The
increase in the intracellular deposition of triglycerides (TG) in muscles, liver and pancreas in …