Despite evidence of insulin resistance and β-cell dysfunction in glucose metabolism in youth
with prediabetes, the relationship between adipose tissue insulin sensitivity (ATIS) and β …

Abstract Background/Objectives Obesity-associated insulin resistance (IR) may develop in
multiple organs, representing different aetiologies towards cardiometabolic diseases. This …

It is well described that excessive lipid metabolism can cause insulin resistance in both
animals and humans, and this has been implicated as a causative factor in the development …

Objective Many overweight/obese subjects appear metabolically healthy with normal in vivo
insulin sensitivity. Still, they have increased long‐term risk of developing type 2 diabetes. We …

Sedentary people have insulin resistance in their skeletal muscle, but whether this also
occurs in fat cells was unknown. Insulin inhibition of hydrolysis of triglycerides (antilipolysis) …

The etiology of insulin resistance in Type 1 Diabetes (T1D) is unknown, however it affects
approximately 20% of T1D patients. Intramyocellular lipids (IMCL) have been identified as a …

Aims/hypothesis Intramyocellular lipids, including diacylglycerol (DAG) and ceramides, have
been linked to insulin resistance. This randomised repeated-measures study examined the …

BACKGROUND AND AIMS: Lipids are needed for optimal glucose-stimulated insulin
secretion (GSIS), and long-chain acyl-CoA (LC-CoA) has been suggested as one candidate …

Background Insulin resistance not only occurs in obesity, but also in lipodystrophy. Although
adipose tissue mass affects metabolic fluxes and participates in interorgan crosstalk, the role …

The purpose of this study was to determine if a high-fat diet would result in a higher lipolytic
rate in subcutaneous adipose tissue than a lower-fat diet in sedentary nonlean men. Six …