Background/Aim: Microsatellite instability (MSI) results from genetic alterations involving the
mismatch repair (MMR) genes MLH1, PSM2, MSH2, and MSH6. MSI has been implicated in …

Abstract Knowledge of population carrier frequency for DNA mismatch repair (MMR) gene
mutations would contribute to understanding the burden of cancer due to genetic …

Mismatch repair (MMR) genes play an important role in the occurrence and development of
sporadic colorectal cancer; however, the effect of MMR genes on clinicopathological …

Determination of microsatellite instability (MSI)/mismatch repair (MMR) status in cancer has
several clinical implications. Our aim was to integrate MSI/MMR status from patients tested in …

Throughout their lifetime, cells are subject to extrinsic and intrinsic mutational processes
leaving behind characteristic signatures in the genome. DNA mismatch repair (MMR) …

Deficiencies in DNA mismatch repair (MMR) result in increased mutation rates and cancer
risk in both humans and mice. Mouse strains homozygous for knockouts of either the Pms2 …

Background Lynch syndrome, the most common colorectal cancer (CRC) syndrome, is
caused by germline mismatch repair (MMR) genes. Precise estimates of age-specific risks …

Background Epigenetic alterations of DNA mismatch repair (MMR) genes are associated
with risk of gastric cancer (GC) by causing microsatellite instability (MSI). Less understood is …

Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch
repair variants: findings from the Prospective Lynch Syndrome Database | Genetics in …

Methylation of the MLH1 gene promoter region is an underlying cause of colorectal cancer
(CRC) with high microsatellite instability (MSI-H) diagnosed in persons without a germ line …