Evolutionary genomics of epidemic and nonepidemic strains of Pseudomonas aeruginosa

JR Dettman, N Rodrigue, SD Aaron… - Proceedings of the …, 2013 - National Acad Sciences
Pseudomonas aeruginosa is an opportunistic pathogen of humans and is a major cause of
morbidity and mortality in patients with cystic fibrosis (CF). Prolonged infection of the …

Deletion and acquisition of genomic content during early stage adaptation of Pseudomonas aeruginosa to a human host environment

MH Rau, RL Marvig, GD Ehrlich… - Environmental …, 2012 - Wiley Online Library
Adaptation of bacterial pathogens to a permanently host‐associated lifestyle by means of
deletion or acquisition of genetic material is usually examined through comparison of …

[HTML][HTML] Evaluation of a microarray-hybridization based method applicable for discovery of single nucleotide polymorphisms (SNPs) in the Pseudomonas aeruginosa …

A Dötsch, C Pommerenke, F Bredenbruch, R Geffers… - BMC genomics, 2009 - Springer
Background Whole genome sequencing techniques have added a new dimension to
studies on bacterial adaptation, evolution and diversity in chronic infections. By using this …

Compendium-wide analysis of Pseudomonas aeruginosa core and accessory genes reveals transcriptional patterns across strains PAO1 and PA14

AJ Lee, G Doing, SL Neff, T Reiter, DA Hogan… - …, 2023 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic pathogen that causes difficult-to-treat
infections. Two well-studied divergent P. aeruginosa strain types, PAO1 and PA14, have …

[HTML][HTML] Pseudomonas aeruginosa clinical and environmental isolates constitute a single population with high phenotypic diversity

MV Grosso-Becerra, C Santos-Medellín… - BMC genomics, 2014 - Springer
Background Pseudomonas aeruginosa is an opportunistic pathogen with a high incidence
of hospital infections that represents a threat to immune compromised patients. Genomic …

Molecular epidemiology of clinically high‐risk Pseudomonas aeruginosa strains: Practical overview

T Sawa, K Momiyama, T Mihara… - Microbiology and …, 2020 - Wiley Online Library
In recent years, numerous outbreaks of multidrug‐resistant Pseudomonas aeruginosa have
been reported across the world. Once an outbreak occurs, besides routinely testing isolates …

In Vivo Regulation of Virulence in Pseudomonas aeruginosa Associated with Genetic Rearrangement

DE Woods, PA Sokol, LE Bryan… - Journal of Infectious …, 1991 - academic.oup.com
Achronic pulmonary infection model was used to induce conversionto the mucoid phenotype
by Pseudomonas aeruginosa PAO. At 6 months after initial inoculation, organisms isolated …

Integrated whole‐genome screening for Pseudomonas aeruginosa virulence genes using multiple disease models reveals that pathogenicity is host specific

JF Dubern, C Cigana, M De Simone… - Environmental …, 2015 - Wiley Online Library
P seudomonas aeruginosa is a multi‐host opportunistic pathogen causing a wide range of
diseases because of the armoury of virulence factors it produces, and it is difficult to …

Interclonal gradient of virulence in the Pseudomonas aeruginosa pangenome from disease and environment

R Hilker, A Munder, J Klockgether… - Environmental …, 2015 - Wiley Online Library
The population genomics of P seudomonas aeruginosa was analysed by genome
sequencing of representative strains of the 15 most frequent clonal complexes in the P …

Role of horizontal gene transfer in the evolution of Pseudomonas aeruginosa virulence

X Qiu, BR Kulasekara, S Lory - Microbial pathogenomics, 2009 - karger.com
The opportunistic pathogen Pseudomonas aeruginosa causes serious infections in
immunocompromised patients and individuals with cystic fibrosis (CF). It is one of the most …