Novel photoactivatable substrates for Renilla luciferase imaging in vitro and in vivo

C Zhang, L Cheng, G Dong, G Han, X Yang… - Organic & …, 2018 - pubs.rsc.org
To develop a photoactivatable bioluminescence imaging technique, a set of high and
efficient photoactivatable substrates for Renilla luciferase has been well designed and …

Photoactivable bioluminescent probes for imaging luciferase activity

Q Shao, T Jiang, G Ren, Z Cheng, B Xing - Chemical communications, 2009 - pubs.rsc.org
Photoactivable bioluminescent probes for imaging luciferase activity - Chemical
Communications (RSC Publishing) DOI:10.1039/B908346D Royal Society of Chemistry View …

Prolonged bioluminescence imaging in living cells and mice using novel pro-substrates for Renilla luciferase

M Yuan, X Ma, T Jiang, Y Gao, Y Cui… - Organic & …, 2017 - pubs.rsc.org
The prodrug or caged-luciferin strategy affords an excellent platform for persistent
bioluminescence imaging. In the current work, we designed and synthesized ten novel pro …

Rapid and scalable assembly of firefly luciferase substrates

DC McCutcheon, WB Porterfield… - Organic & biomolecular …, 2015 - pubs.rsc.org
Bioluminescence imaging with luciferase–luciferin pairs is a popular method for visualizing
biological processes in vivo. Unfortunately, most luciferins are difficult to access and remain …

Design and synthesis of an alkynyl luciferin analogue for bioluminescence imaging

RC Steinhardt, JM O'Neill, CM Rathbun… - … A European Journal, 2016 - Wiley Online Library
Herein, the synthesis and characterization of an alkyne‐modified luciferin is reported. This
bioluminescent probe was accessed using C− H activation methodology and was found to …

Brominated luciferins are versatile bioluminescent probes

RC Steinhardt, CM Rathbun, BT Krull, JM Yu… - …, 2017 - Wiley Online Library
We report a set of brominated luciferins for bioluminescence imaging. These regioisomeric
scaffolds were accessed by using a common synthetic route. All analogues produced light …

Beyond luciferase-luciferin system: Modification, improved imaging and biomedical application

Y Jiang, X Shi, C Tang, F Wang - Coordination Chemistry Reviews, 2023 - Elsevier
The bioluminescence signal generated by the luciferase-luciferin interaction, exploited for
real-time and continuous monitoring of numerous biochemical processes in living cells and …

D-luciferin analogues: a multicolor toolbox for bioluminescence imaging.

YQ Sun, J Liu, P Wang, J Zhang… - … Chemie (International ed …, 2012 - europepmc.org
Colorful mixture: Three types of luciferin analogues, that is, alkylaminoluciferins,
aminoselenoluciferin, and luciferins with a benzimidazole scaffold, have been reported …

Multicomponent bioluminescence imaging with a π-extended luciferin

Z Yao, BS Zhang, RC Steinhardt, JH Mills… - Journal of the …, 2020 - ACS Publications
Bioluminescence imaging with luciferase-luciferin pairs is commonly used for monitoring
biological processes in cells and whole organisms. Traditional bioluminescent probes are …

Activity‐Based Luciferase‐Luciferin Bioluminescence System for Bioimaging Applications

T Xia, X Cheng, W Zhan, G Liang - Analysis & Sensing, 2021 - Wiley Online Library
There is growing interest in applying bioluminescence for imaging varies biological
processes in life sciences due to its high resolution, selectivity, and signal/noise ratio (no …