Various strategies have been explored to overcome critically sized bone defects via bone
tissue engineering approaches that incorporate biomimetic scaffolds. Biomimetic scaffolds …

Critical-sized bone defect repair remains a substantial challenge in clinical settings and
requires bone grafts or bone substitute materials. However, existing biomaterials often do …

Over the last decade, bone engineered tissues have been developed as alternatives to
autografts and allografts to repair and reconstruct bone defects. This article provides a …

Bone tissue engineering approaches have evolved towards addressing the challenges of
tissue mimetic requirements over the years. Different strategies have been combining …

Vascularization in bone tissues is essential for the distribution of nutrients and oxygen, as
well as the removal of waste products. Fabrication of tissue-engineered bone constructs with …

In Bone Tissue Engineering (BTE), autologous bone-regenerative cells are combined with a
scaffold for large bone defect treatment (LBDT). Microporous, polylactic acid (PLA) scaffolds …

The successful regeneration of functional bone tissue in critical‐size defects remains a
significant clinical challenge. To address this challenge, synthetic bone scaffolds are widely …

The integration of structure and function for tissue engineering scaffolds is of great
importance in mimicking native bone tissue. However, the complexity of hierarchical …

The integration of hierarchical structure, chemistry, and functional activity within tissue‐
engineered scaffolds is of great importance in mimicking native bone tissue. Bone is a highly …

Tissue engineering is promising in realizing successful treatments of human body tissue
loss that current methods cannot treat well or achieve satisfactory clinical outcomes. In …