CD8+ T cells are central players in controlling infections and cancer. Longevity, functionality,
and metabolic fitness are critical determinants of T cell efficacy in cancer immunotherapy …

T cells play important roles in anti-tumor immunity. Emerging evidence has revealed that
distinct metabolic changes impact the activation and differentiation of T cells. Tailoring …

T cell metabolism has a central role in supporting and shaping immune responses and may
have a key role in antitumor immunity. T cell metabolism is normally held under tight …

The metabolic stress occurring in the tumor microenvironment (TME) hampers T cell anti-
tumor immunity by disturbing T cell metabolic and epigenetic programs. Recent studies are …

The development of immunotherapies over the past decade has resulted in a paradigm shift
in the treatment of cancer. However, the majority of patients do not benefit from …

Tumor microenvironment is characterized by a consistent reduction in oxygen and blood-
borne nutrients that significantly affects the metabolism of distinct cell subsets. Immune cells …

In the past several years a wealth of evidence has emerged illustrating how metabolism
supports many aspects of T cell biology, as well as how metabolic changes drive T cell …

The metabolic programs that drive T cell functions are exquisitely sensitive to cell intrinsic
and extrinsic factors, allowing T cells to respond in a fine-tuned manner to a variety of …

There has been significant progress in utilizing our immune system against cancer, mainly
by checkpoint blockade and T cell-mediated therapies. The field of cancer immunotherapy is …

Immune oncology approaches of adoptive cell therapy and immune checkpoint blockade
aim to activate T cells to eliminate tumors. Normal stimulation of resting T cells induces …