Infarct scar tissue has long been considered inert (acellular, composed simply of fibrillar
collagen) and whose function is simply to restore structural integrity to infarcted myocardium …

Infarct scar, a requisite to the rebuilding of necrotic myocardium following myocardial
infarction (MI), has long been considered inert. Earlier morphologic studies suggested …

Cardiac scars, often dubbed 'dead tissue', are very much alive, with heterocellular activity
contributing to the maintenance of structural and mechanical integrity following heart injury …

Myocardial infarction (MI) is a major source of morbidity and mortality worldwide, with over 7
million people suffering infarctions each year. Heart muscle damaged during MI is replaced …

Once myocardium dies during a heart attack, it is replaced by scar tissue over the course of
several weeks. The size, location, composition, structure and mechanical properties of the …

Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate
acute wound healing and long-term tissue remodeling with scarring. With myocardial …

The pathological processes leading to heart failure are characterized by the formation of
fibrosis and scar, yet the dynamics of scar production and removal are incompletely …

Angiogenesis is a critical process in healing of myocardial infarcts, leading to the formation
of highly vascular granulation tissue. However, effective cardiac repair depends on …

In the adult, tissue repair after injury is generally compromised by fibrosis, which maintains
tissue integrity with scar formation but does not restore normal architecture and function. The …

During healing after myocardial infarction, scar collagen content and stiffness do not
correlate. We studied regional mechanics and both area fraction and orientation of large …