Nuclear oncogene products have the potential to induce alterations in gene regulation
leading to the genesis of cancer. The biochemical mechanisms by which nuclear …

Proto-oncogenes encode proteins with three main sites of action: the cell-surface
membrane, the cytoplasm and the nucleus1, 2. Although the exact biochemical function of …

The discovery that the AP-1 family of enhancer binding factors includes a complex of the
cellular Fos (cFos) and cellular Jun (cJun) proteins established a direct and important link …

The protooncogene c-jun encodes a component of the transcription factor AP-1. Both murine
c-jun and a related gene (jun-B) are rapidly activated in BALB/c3T3 cells by serum growth …

The c-jun and c-fos proto-oncogenes encode proteins that form a complex which regulates
transcription from promoters containing AP-1 activation elements. c&n has specific DNA …

The human proto-oncogene product, cJun, is a member of the AP-1 family of transcription
factors, which mediate the regulation of gene expression in response to extracellular …

The response of a cell to mitogens and differentiation agents involves the transcriptional
induction of several cellular genes. Prominent among these so-called'immediate …

The jun oncogene of ASV17 is expressed as a 65 kd protein (p65 gag-jun) that contains
partial gag sequences at its amino terminus fused to jun sequences that make up the …

The proto-oncogene products c-Fos and c-Jun heterodimerize through their leucine zippers
to form the AP-1 transcription factor. The transcriptional activity of the heterodimer is …

We have previously reported that one of the genes that is rapidly induced in mouse 3T3 cells
by serum growth factors (jun-B) encodes a protein related to the onco-protein v-jun. By using …