Biological tissue sample preparation for time-of-flight secondary ion mass spectrometry (ToF–SIMS) imaging

S Yoon, TG Lee - Nano Convergence, 2018 - Springer
Time-of-flight secondary ion mass spectrometry (ToF–SIMS) imaging is an analytical
technique rapidly expanding in use in biological studies. This technique is based on high …

A concise tutorial review of TOF-SIMS based molecular and cellular imaging

P Massonnet, RMA Heeren - Journal of Analytical Atomic Spectrometry, 2019 - pubs.rsc.org
This concise tutorial review provides a description of the current state of the art in the
application of time-of flight based secondary ion mass spectrometry (TOF-SIMS) in the field …

Biomedical studies by TOF-SIMS imaging

C Bich, D Touboul, A Brunelle - Biointerphases, 2015 - pubs.aip.org
Imaging by secondary ion mass spectrometry coupled to time-of-flight mass analysis (TOF-
SIMS) is a method of which the applications have greatly increased since 10 years. Taking …

A new dynamic in mass spectral imaging of single biological cells

JS Fletcher, S Rabbani, A Henderson… - Analytical …, 2008 - ACS Publications
Time-of-flight secondary ion mass spectrometry (TOF-SIMS) has unique capabilities in the
area of high-resolution mass spectrometric imaging of biological samples. The technique …

Secondary ion mass spectrometry imaging of tissues, cells, and microbial systems

CR Anderton, LJ Gamble - Microscopy today, 2016 - academic.oup.com
Secondary ion mass spectrometry (SIMS) is a technique capable of imaging tissues, single
cells, and microbes revealing chemical species with sub-micrometer spatial resolution. The …

Recent advances in biological tissue imaging with time-of-flight secondary ion mass spectrometry: polyatomic ion sources, sample preparation, and applications

A Brunelle, O Laprevote - Current pharmaceutical design, 2007 - ingentaconnect.com
Recent technological and methodological improvements have greatly enhanced the
sensitivity of the Time-of-flight Secondary Ion Mass Spectrometry (TOF-SIMS), thus making …

Time‐of‐flight secondary ion mass spectrometry imaging of biological samples with delayed extraction for high mass and high spatial resolutions

QP Vanbellingen, N Elie, MJ Eller… - Rapid …, 2015 - Wiley Online Library
Rationale In Time‐of‐Flight Secondary Ion Mass Spectrometry (TOF‐SIMS), pulsed and
focused primary ion beams enable mass spectrometry imaging, a method which is …

Characterisation of biological material with ToF-SIMS: a review

S Fearn - Materials Science and Technology, 2015 - journals.sagepub.com
Time of flight secondary ion mass spectrometry (ToF-SIMS) has the unique ability to
simultaneously obtain chemical information (elemental and molecular) with its spatial …

Advancements in ToF-SIMS imaging for life sciences

F Jia, X Zhao, Y Zhao - Frontiers in Chemistry, 2023 - frontiersin.org
In the last 2 decades, Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) has
gained significant prominence as a powerful imaging technique in the field of life sciences …

Imaging and differentiation of mouse embryo tissues by ToF-SIMS

L Wu, X Lu, KS Kulp, MG Knize, ESF Berman… - International Journal of …, 2007 - Elsevier
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) equipped with a gold ion gun
was used to image mouse embryo sections and differentiate tissue types (brain, spinal cord …