Abstract Astragaloside IV (AS-IV) exhibits diverse biological activities. Despite this, the
detailed molecular mechanisms by which AS-IV ameliorates diabetic nephropathy (DN) and …

Defective antioxidant system as well as mitochondrial dysfunction contributes to the
pathogenesis and progression of diabetic kidney disease (DKD). Nuclear factor erythroid 2 …

Astragaloside II (AS II), a novel saponin purified from Astragalus membranes, has been
reported to modulate the immune response, repair tissue injury, and prevent inflammatory …

Both autophagy and podocyte epithelial-mesenchymal transition (EMT) are critical factors in
glomerular diseases that involve proteinuria and fibrosis. Here, we sought to determine …

The aim of this study was to investigate the effect and possible mechanism of Astragaloside
IV (AS-IV) on retarding the progression of diabetic nephropathy (DN) in a type 2 diabetic …

Aberrant endoplasmic reticulum (ER) stress and autophagy are associated with diabetic
nephropathy. Here we investigated the effect of astragaloside IV (AS-IV) on the progression …

Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) plays a central role in the
pathogenesis of diabetes. This protein has been recognized as a potential target for diabetic …

Excessive generation of mitochondrial reactive oxygen species (ROS) is considered to be
initiating event in the development of diabetic nephropathy (DN). Mitochondrial biosynthesis …

Aims Podocyte apoptosis plays an important role in the pathogenesis of diabetic
nephropathy (DN). Astragaloside IV (AS-IV) has been shown to protect against podocyte …

Introduction: Chronic kidney disease (CKD) can lead to significant elevation of 1-
deoxysphingolipids (1-deoxySL). The increase of 1-deoxySL in turn can result in …