Synthetic and natural naphthofuranquinones were tested in vitro against three Trypanosoma
cruzi strains with different drug susceptibility to nifurtimox and benznidazole in vivo. Four …

A series of new 2-aminonaphthoquinones and related compounds were synthesized and
evaluated in vitro as trypanocidal and cytotoxic agents. Some tested compounds inhibited …

Four new naphthofuranquinones, obtained from 2-hydroxy-3-allyl-naphthoquinone (1) and
nor-lapachol (2), have their structures established by physical and X-ray analysis and their …

Naphtho [2, 3-b] thiophen-4, 9-quinone and five derivatives were prepared using the Friedel-
Crafts reaction and tandem-lithiation of aromatic diethylamides. These quinones were …

The antitrypanosomal activities, cytotoxicity, and selectivity indices of eleven imido-
substituted 1, 4-naphthoquinone derivatives and nifurtimox have been studied. Compared to …

Eight novel analogues of Nifurtimox, 4-[(5-nitrofurfurylidene) amino]-3-methylthiomorpholine-
1, 1-dioxide, containing alfa–beta unsaturated amides, were synthesized and evaluated for …

The importance of American trypanosomiasis (Chagas' disease) in human pathology is
widely known. The prognosis of this disease is poor and the choice of effective medicines …

A series of naphthoquinone derivatives has been synthesized and tested for its biological
activity against human African trypanosomiasis. The use of reverse micellar medium not only …

The discovery and development of essential drugs for Chagas disease is a major concern
worldwide. New substituted 1, 4-naphthoquinones were synthesized and tested against the …

Objectives: Investigation of the mode of action of the naphthoimidazole N1, obtained from
the reaction of β-lapachone with benzaldehyde, which among 45 semi-synthetic derivatives …