Quinoxaline derivatives presented good inhibitor activity of growth of Trypanosoma cruzi in
in vitro assays. The 50% inhibitory doses were of the same order of that of Nifurtimox …

A series of over a hundred furoxans, alkylnitrates and related compounds were studied as
growth inhibitors of the two major kinetoplastids of Latin America, Trypanosoma cruziand …

Chagas disease, caused by Trypanosoma cruzi, is a widespread infection in Latin America.
Currently, only 2 partially effective and highly toxic drugs, ie, benznidazole and nifurtimox …

The naphthoquinones 2-hydroxy-3-(1, 1-dimethylallyl)-1, 4-naphthoquinone (CS-1),(−)-2, 3,
3-trimethyl-2–3-dihydronaphtho [2, 3-b] furan-4, 9-quinone (CS-3), and 2-acetoxy-3-(1, 1 …

A series of bis‐naphthoquinone derivatives prepared by condensation of aryl aldehydes
with lawsone were tested for antiparasitic activities against Toxoplasma gondii and …

A series of new phthalazine derivatives (1–4) containing imidazole rings and functionalized
with nitro groups in the benzene ring of the phthalazine moiety were prepared and identified …

In the search for new therapeutic alternatives for Chagas disease, a series of six aryloxy-
naphthoquinone derivatives were synthesized and evaluated in vitro against Trypanosoma …

The investigation of trypanocidal effects against Trypanosoma cruzi and cytotoxicity in VERO
cell line of several oxyranes structurally related to β-lapachone, nor-β-lapachone, α …

Chagas disease is one of the most important endemic diseases in Latin America, caused by
Trypanosoma cruzi. The drugs used for the treatment of this disease, nifurtimox and …

The discovery of new secondary metabolites from natural origins has become more
challenging in natural products research. Different approaches have been applied to target …