The persistence of the coronavirus disease 2019 (COVID-19) pandemic has resulted in
increasingly disruptive impacts, and it has become the most devastating challenge to global …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed millions of
people and continues to cause massive global upheaval. Coronaviruses are positive-strand …

The current coronavirus disease-2019 (COVID-19) pandemic is due to the novel coronavirus
SARS-CoV-2. The scientific community has mounted a strong response by accelerating …

Coronaviruses use an RNA-dependent RNA polymerase (RdRp) to replicate and express
their genome. The RdRp associates with additional non-structural proteins (nsps) to form a …

The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive
impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the …

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), is an unprecedented global health crisis. However, therapeutic options for …

Abstract SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), as well as
SARS-CoV from 2003 along with MERS-CoV from 2012, is a member of the Betacoronavirus …

Beginning in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
emerged as a novel pathogen that causes coronavirus disease 2019 (COVID-19). SARS …

Coronavirus (CoV) nonstructural proteins (nsps) assemble to form the replication–
transcription complex (RTC) responsible for viral RNA synthesis. nsp7 and nsp8 are …

The replication transcription complex (RTC) from the virus SARS-CoV-2 is responsible for
recognizing and processing RNA for two principal purposes. The RTC copies viral RNA for …