Background: Influenza, the most important viral infection affecting older adults, produces a
substantial burden in health care costs, morbidity, and mortality. Influenza vaccination …

Background Immune responses to influenza vaccines decline with age, reducing clinical
effectiveness. We compared the effect of the more immunogenic high-dose trivalent …

Influenza severity increases and vaccine effectiveness decreases with age. High-dose
influenza vaccine (HD) with quadruple the antigen of standard-dose (SD) vaccine is more …

Introduction Influenza infection is common among institutionalized older adults. Many
nonrandomized observational studies on influenza vaccination suggested that it could …

Objective: Each year, influenza and its complications account for 10,000-40,000 excess
deaths in the United States. Over 80% of these deaths occur among the elderly. The …

Objectives Influenza is a leading cause of avoidable admissions for nursing home (NH)
residents. We previously evaluated the effectiveness of a high-dose trivalent influenza …

OBJECTIVES: To determine whether assessing seroprotection after influenza vaccine and
administering booster vaccination where not achieved reduces hospitalization and death. To …

Background Reliable estimates of the effectiveness of influenza vaccine among persons 65
years of age and older are important for informed vaccination policies and programs. Short …

We estimated the effectiveness of influenza vaccines in preventing laboratory-confirmed
influenza among older adults in aged care. Electronic database searches were conducted …

Objective: To quantify the protective efficacy of influenza vaccine in elderly persons. Data
Sources: A MEDLINE search was done using the index terms influenza vaccine, vaccine …