The binding sites of Cys-loop receptors are formed from at least six loops (A− F). Here we
have used mutagenesis, radioligand binding, voltage clamp electrophysiology, and …

We have used a homology model of the extracellular domain of the 5-HT 3 receptor to dock
granisetron, a 5-HT 3 receptor antagonist, into the binding site using AUTODOCK. This …

A new homology model of type-3A serotonin receptors (5-HT3ARs) was built on the basis of
the electron microscopic structure of the nicotinic acetylcholine receptor and with an agonist …

To better understand G-protein-coupled receptor (GPCRs) signaling, cellular and animal
physiology, as well as gene therapy, a new tool has recently been proposed. It consists of …

The serotonin type 3 receptor (5-HT3R) is a member of the cys-loop ligand-gated ion
channel (LGIC) superfamily. Like almost all membrane proteins, high-resolution structural …

The ligand binding pocket of Cys-loop receptors consists of a number of binding loops
termed A–F. Here we examine the 5-HT3 receptor loop A residues Asn-128, Glu-129 and …

The 5-HT 3 receptor belongs to a family of therapeutically important neurotransmitter-gated
receptors whose ligand binding sites are formed by the convergence of six peptide loops …

The 5-HT 3 receptor is a member of the Cys-loop family of ligandgated ion channels. The
extracellular domains of these proteins contain six amino acid loops (A–F) that converge to …

A body of evidences suggests that a hydrophobic pocket of the human 5‐HT4 receptor
contributes to the high affinity of some bulky 5‐HT4 ligands. A thorough study of this pocket …

Background Lerisetron, a competitive serotonin type 3 receptor (5-HT 3 R) antagonist,
contains five functional groups capable of interacting with amino acids in the 5-HT 3 R …