Evasion of immunity to Plasmodium falciparum malaria by IgM masking of protective IgG epitopes in infected erythrocyte surface-exposed PfEMP1
L Barfod, MB Dalgaard, ST Pleman… - Proceedings of the …, 2011 - National Acad Sciences
Plasmodium falciparum malaria is a major cause of mortality and severe morbidity. Its
virulence is related to the parasite's ability to evade host immunity through clonal antigenic …
virulence is related to the parasite's ability to evade host immunity through clonal antigenic …
Generation of Cross-Protective Antibodies against Plasmodium falciparum Sequestration by Immunization with an Erythrocyte Membrane Protein 1-Duffy Binding …
K Moll, F Pettersson, AM Vogt, C Jonsson… - Infection and …, 2007 - Am Soc Microbiol
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is an important
virulence factor on the surface of infected erythrocytes. Naturally acquired antibodies to …
virulence factor on the surface of infected erythrocytes. Naturally acquired antibodies to …
Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG
MD Larsen, MP Quintana, SB Ditlev… - Frontiers in …, 2019 - frontiersin.org
Members of the PfEMP1 protein family are expressed on the surface of P. falciparum-
infected erythrocytes (IEs), where they contribute to the pathogenesis of malaria and are …
infected erythrocytes (IEs), where they contribute to the pathogenesis of malaria and are …
[HTML][HTML] CD4+ T cell responses to the Plasmodium falciparum erythrocyte membrane protein 1 in children with mild malaria
EN Gitau, J Tuju, H Karanja, L Stevenson… - The Journal of …, 2014 - journals.aai.org
The immune response against the variant surface Ag Plasmodium falciparum erythrocyte
membrane protein 1 (PfEMP1) is a key component of clinical immunity against malaria. We …
membrane protein 1 (PfEMP1) is a key component of clinical immunity against malaria. We …
[HTML][HTML] Identification of the minimal binding region of a Plasmodium falciparum IgM binding PfEMP1 domain
JP Semblat, A Ghumra, DM Czajkowsky… - Molecular and …, 2015 - Elsevier
Binding of host immunoglobulin is a common immune evasion mechanism demonstrated by
microbial pathogens. Previous work showed that the malaria parasite Plasmodium …
microbial pathogens. Previous work showed that the malaria parasite Plasmodium …
PfEMP1: an antigen that plays a key role in the pathogenicity and immune evasion of the malaria parasite Plasmodium falciparum
ND Pasternak, R Dzikowski - The international journal of biochemistry & …, 2009 - Elsevier
The deadliest form of human malaria is caused by the protozoan parasite Plasmodium
falciparum affecting millions worldwide every year. P. falciparum virulence is attributed to its …
falciparum affecting millions worldwide every year. P. falciparum virulence is attributed to its …
[HTML][HTML] Mapping the binding site of a cross-reactive Plasmodium falciparum PfEMP1 monoclonal antibody inhibitory of ICAM-1 binding
F Lennartz, A Bengtsson, RW Olsen… - The journal of …, 2015 - journals.aai.org
The virulence of Plasmodium falciparum is linked to the ability of infected erythrocytes (IE) to
adhere to the vascular endothelium, mediated by P. falciparum erythrocyte membrane …
adhere to the vascular endothelium, mediated by P. falciparum erythrocyte membrane …
Sequential, ordered acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 domains
The binding of erythrocytes infected with mature blood stage parasites to the vascular bed is
key to the pathogenesis of malignant malaria. The binding is mediated by members of …
key to the pathogenesis of malignant malaria. The binding is mediated by members of …
Immunization with VAR2CSA-DBL5 Recombinant Protein Elicits Broadly Cross-Reactive Antibodies to Placental Plasmodium falciparum-Infected Erythrocytes
M Avril, MM Cartwright, MJ Hathaway… - Infection and …, 2010 - Am Soc Microbiol
Pregnancy-associated malaria is a severe clinical syndrome associated with the
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …
Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination
MD Larsen, M Lopez-Perez, EK Dickson… - Nature …, 2021 - nature.com
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family members mediate
receptor-and tissue-specific sequestration of infected erythrocytes (IEs) in malaria. Antibody …
receptor-and tissue-specific sequestration of infected erythrocytes (IEs) in malaria. Antibody …