Plasmodium falciparum: VAR2CSA expressed during pregnancy-associated malaria is partially resistant to proteolytic cleavage by trypsin

MA Nielsen, M Resende, M Alifrangis, L Turner… - Experimental …, 2007 - Elsevier
In areas of high Plasmodium falciparum transmission, immunity to malaria is acquired during
childhood, so that adults in general are clinically immune. One exception is that first-time …

Limited Cross-Reactivity among Domains of the Plasmodium falciparum Clone 3D7 Erythrocyte Membrane Protein 1 Family

L Joergensen, L Turner, P Magistrado… - Infection and …, 2006 - Am Soc Microbiol
The var gene-encoded Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)
family is responsible for antigenic variation and sequestration of infected erythrocytes during …

Identification of residues in the Cμ4 domain of polymeric IgM essential for interaction with Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)

A Ghumra, JP Semblat, RS McIntosh… - The Journal of …, 2008 - journals.aai.org
The binding of nonspecific human IgM to the surface of infected erythrocytes is important in
rosetting, a major virulence factor in the pathogenesis of severe malaria due to Plasmodium …

Neonatal and Maternal Immunological Responses to Conserved Epitopes within the DBL-γ3 Chondroitin Sulfate A-Binding Domain of Plasmodium falciparum …

K Brustoski, M Kramer, U Möller… - Infection and …, 2005 - Am Soc Microbiol
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates the adherence
of P. falciparum-infected erythrocytes to placental syncytiotrophoblasts via interactions with …

[HTML][HTML] A novel domain cassette identifies Plasmodium falciparum PfEMP1 proteins binding ICAM-1 and is a target of cross-reactive, adhesion-inhibitory antibodies

A Bengtsson, L Joergensen, TS Rask… - The Journal of …, 2013 - journals.aai.org
Cerebral Plasmodium falciparum malaria is characterized by adhesion of infected
erythrocytes (IEs) to the cerebral microvasculature. This has been linked to parasites …

PfEMP1–a parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis

L Hviid, ATR Jensen - Advances in parasitology, 2015 - Elsevier
Plasmodium falciparum causes the most severe form of malaria and is responsible for
essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes …

Classification of adhesive domains in the Plasmodium falciparum erythrocyte membrane protein 1 family

JD Smith, G Subramanian, B Gamain, DI Baruch… - Molecular and …, 2000 - Elsevier
The Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) family of
cytoadherent proteins has a central role in disease from malaria infection. This highly …

[HTML][HTML] Plasmodium falciparum erythrocyte membrane protein-1 specifically suppresses early production of host interferon-γ

MC D'Ombrain, TS Voss, AG Maier, JA Pearce… - Cell host & …, 2007 - cell.com
Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a variable antigen
expressed by P. falciparum, the malarial parasite. PfEMP-1, present on the surface of …

[HTML][HTML] Plasmodium falciparum Erythrocyte Membrane Protein 1 Diversity in Seven Genomes – Divide and Conquer

TS Rask, DA Hansen, TG Theander… - PLoS computational …, 2010 - journals.plos.org
The var gene encoded hyper-variable Plasmodium falciparum erythrocyte membrane
protein 1 (PfEMP1) family mediates cytoadhesion of infected erythrocytes to human …

Plasmodium falciparum erythrocyte membrane protein 1 is a parasitized erythrocyte receptor for adherence to CD36, thrombospondin, and intercellular adhesion …

DI Baruch, JA Gormely, C Ma… - Proceedings of the …, 1996 - National Acad Sciences
Adherence of mature Plasmodium falciparum parasitized erythrocytes (PRBCs) to
microvascular endothelium contributes directly to acute malaria pathology. We affinity …