It is well known that the immune response decreases during aging, leading to a higher
susceptibility to infections, cancers and autoimmune disorders. Most widely studied have …

Human neutrophils are activated by a wide array of compounds through their receptors. This
elicits their classical functions, such as chemotaxis, phagocytosis, and the production of …

In the armoury of the immune system developed to combat the various micro‐organisms that
could invade the host, the neutrophil forms the first line of defence against rapidly dividing …

Highlights•Neutrophils are increasingly recognized as multi-faceted immune cells.•In aged
hosts, neutrophils show inaccurate chemotaxis and reduced NET formation.•Neutrophils …

As humans age, their morbidity and mortality from infection increases, their response to
vaccination declines and they have an increased incidence of inflammatory diseases and …

Despite increasing longevity, many old people are not in good health. There has been an
increase in the prevalence of age-associated multi-morbidity (two or more chronic conditions …

A fully functioning immune system is essential in order to maintain good health. However,
the immune system deteriorates with advancing age, and this contributes to increased …

Due to age-related changes of the immune system, elderly people are more susceptible to
microbial infections than the young. Most research concerning immune senescence has …

Neutrophils are first-responders, providing early protection against invading pathogens.
Recent findings have revealed a temporal dimension to neutrophil function, associated with …

Components of the innate immune response, including neutrophils and macrophages, are
the first line of defense against infections. Their role is to initiate an inflammatory response …