The recent identification of a number of T lymphocytespecific enhancers has allowed the
cloning of several novel transcription factors. Two of these, TCF-1 and LEF-1, contain a …

We and others have recently cloned two related human lymphoid transcription factors, TCF-
1 and TCF-la (1, 2). Both factors contain a virtually identical version of a novel type of DNA …

Abstract LEF-1 is a 54-kDa nuclear protein that is expressed specifically in pre-B and T-cells.
It binds to a functionally important site in the T-cell receptor α enhancer and contributes to …

The family of T‐cell factor (Tcf) and lymphoid enhancer factor (Lef) proteins, which in
mammals comprises Tcf1, Lef1, Tcf3 and Tcf4, form a subgroup of the high mobility group …

Abstract hLEF/TCF-1 alpha is a lymphoid cell-specific HMG protein that activates the distal
enhancer of the gene encoding the alpha-subunit of the T-cell receptor (TCR alpha). We …

Lymphoid enhancer-binding factor 1 (LEF-1) is a pre-B and T lymphocyte-specific nuclear
protein that participates in the regulation of the T-cell antigen receptor (TCR) alpha …

Previous studies in lymphocytes have described two DNA‐binding HMG box proteins, TCF‐
1 and LEF‐1, with affinity for the A/TA/TCAAAG motif found in several T cell‐specific …

The human T cell-specific transcription factor TCF-1 alpha plays a key role in the tissue-
specific activation of the T cell receptor (TCR) C alpha enhancer and binds to pyrimidine-rich …

We have recently isolated cDNA clones representing four alternative splice forms of a T cell-
specific transcription factor, TCF-1. Here we report the characterization of the human gene …

Lymphoid enhancer factor 1 (LEF‐1) is a member of the high mobility group (HMG) family of
proteins and participates in the regulation of the T cell receptor (TCR) alpha enhancer. We …