Fundamentals and developments in fluorescence-guided cancer surgery

JSD Mieog, FB Achterberg, A Zlitni… - Nature reviews Clinical …, 2022 - nature.com
Fluorescence-guided surgery using tumour-targeted imaging agents has emerged over the
past decade as a promising and effective method of intraoperative cancer detection. An …

Optical molecular imaging for tumor detection and image-guided surgery

C Wang, Z Wang, T Zhao, Y Li, G Huang, BD Sumer… - Biomaterials, 2018 - Elsevier
We have witnessed rapid development of fluorescence molecular imaging of solid tumors for
cancer diagnosis and image-guided surgery in the past decade. Many biomarkers unique to …

Development of tumor-targeted near infrared probes for fluorescence guided surgery

LE Kelderhouse, V Chelvam, C Wayua… - Bioconjugate …, 2013 - ACS Publications
Complete surgical resection of malignant disease is the only reliable method to cure cancer.
Unfortunately, quantitative tumor resection is often limited by a surgeon's ability to locate all …

Molecular probes for fluorescence image-guided cancer surgery

R Ito, M Kamiya, Y Urano - Current Opinion in Chemical Biology, 2022 - Elsevier
In cancer surgery, complete surgical resection of tumor lesions is critical to optimize the
outcome. However, it is sometimes difficult to distinguish the boundary between tumor and …

[HTML][HTML] Challenges and opportunities to penetrate the blood-brain barrier for brain cancer therapy

DH Upton, C Ung, SM George, M Tsoli, M Kavallaris… - Theranostics, 2022 - ncbi.nlm.nih.gov
Despite significant advances in research, the prognosis for both primary and secondary
brain cancers remains poor. The blood-brain barrier (BBB) is a complex and unique semi …

[HTML][HTML] Intraoperative imaging-guided cancer surgery: from current fluorescence molecular imaging methods to future multi-modality imaging technology

C Chi, Y Du, J Ye, D Kou, J Qiu, J Wang, J Tian… - Theranostics, 2014 - ncbi.nlm.nih.gov
Cancer is a major threat to human health. Diagnosis and treatment using precision medicine
is expected to be an effective method for preventing the initiation and progression of cancer …

Fluorescence-guided surgery with live molecular navigation—a new cutting edge

QT Nguyen, RY Tsien - Nature reviews cancer, 2013 - nature.com
A glowing new era in cancer surgery may be dawning. Using fluorescently labelled markers,
surgical molecular navigation means that tumours and nerves can be displayed in real time …

Dual-targeting upconversion nanoprobes across the blood–brain barrier for magnetic resonance/fluorescence imaging of intracranial glioblastoma

D Ni, J Zhang, W Bu, H Xing, F Han, Q Xiao, Z Yao… - Acs Nano, 2014 - ACS Publications
Surgical resection, one of the main clinical treatments of intracranial glioblastoma, bears the
potential risk of incomplete excision due to the inherent infiltrative character of the …

[HTML][HTML] Optical image-guided surgery—where do we stand?

S Keereweer, JDF Kerrebijn, PBAA Van Driel… - Molecular Imaging and …, 2011 - Springer
In cancer surgery, intra-operative assessment of the tumor-free margin, which is critical for
the prognosis of the patient, relies on the visual appearance and palpation of the tumor …

Molecular targeted NIR-II probe for image-guided brain tumor surgery

S Kurbegovic, K Juhl, H Chen, C Qu, B Ding… - Bioconjugate …, 2018 - ACS Publications
Optical imaging strategies for improving delineation of glioblastoma (GBM) is highly desired
for guiding surgeons to distinguish cancerous tissue from healthy and precious brain tissue …