Cumulus cells of pre-pubertal domestic animals are dysfunctional, perhaps due to age-
specific epigenetic events. This study was designed to determine effects of melatonin …

Background DNA methylation is one the epigenetic mechanisms, which is critically involved
in gene expression. This phenomenon is mediated by DNA methyl-transferases and is …

Simple Summary Accurate timing of photoperiod changes is vital for animal reproduction.
Previous research has shown that the polymorphisms and expression of melatonin receptor …

Physical damage and oxidative stress may occur in prepubertal cumulus cells, due to
insufficient glutathione synthesis. To determine potential epigenetic mechanisms related to …

Melatonin (MLT) is an endogenous hormone with roles in animal germ cell development.
However, the effect of MLT on porcine oocyte maturation and its underlying mechanisms …

Melatonin is a multifunctional molecule that mediates several circadian and seasonal
reproductive processes. The exact role of melatonin in modulating reproduction, however, is …

Melatonin is a multifunctional molecule with numerous biological activities. The fact that
melatonin modulates the functions of porcine granulosa cells via the MT2 receptor suggests …

Melatonin is a multifunctional molecule that mediates several circadian and seasonal
processes in animal reproduction. Melatonin and its metabolites are antioxidants and free …

Prolonged culture of metaphase II oocytes is an in vitro aging process that compromises
oocyte quality. We tested whether melatonin preserves epigenetic modifications in oocytes …

The effect of melatonin during in vitro maturation (IVM) on DNA damage of cumulus cells
(CCs) from bovine cumulus–oocyte complexes (COCs) and embryo development was …