Sickle cell disease is a family of inherited haemoglobinopathies resulting from a point
mutation in the gene coding for the ß-chain of haemoglobin, resulting in the substitution of …

Sickle Hemoglobin (HbS) is a variant of human hemoglobin with a point mutation on two
subunits. This mutation causes HbS molecules to grow into polymers when the ligands it …

Sickle cell disorder (SCD) is characterized by the presence of non-deformable red blood
cells. Literature reports indicate that the T-state structure of hemoglobin (Hb)(highly …

Sickle cell anemia is a hematologic disorder impacting over 15 million people worldwide. It
is caused by a single point mutation in the gene hemoglobin-Betha, where a glu group is …

By William A. Eaton, James Hofrichter, and Philip D. Ross T HE FACTORS which determine
the frequency of crises and overall severity in sickle cell disease are still not clear. Although …

Sickle cell disease (SCD) is caused by a point mutation in the β-globin gene leading to
production of hemoglobin S (HbS) that polymerizes under hypoxic conditions with …

Therapeutic solutions to hinder the effects of sickle hemoglobin (HbS) polymerization are
highly sought after. Measuring the kinetics of polymerization of HbS using laser photolysis …

At present there is no specific treatment for sickle cell disease. However, a great deal is
known about the molecular abnormality that produces the disease and the highly abnormal …

Publisher Summary This chapter discusses the sickle cell anemia along with its treatment
with anti-sickling agents. The lack of treatment for sickle cell anemia prevails even though …

Background: Sickle cell disease (SCD) is caused by polymerization of Hemoglobin S,
resulting in red blood cell (RBC) sickling, RBC destruction, vaso-occlusive episodes and …