Sickle cell disease is a genetic disorder that causes red blood cells to form sickle shapes.
These sickle-shaped red blood cells cannot pass through small blood vessels, which in turn …

Five (2, 2-dimethylchroman-6-yl) alkanoic acids were synthesized and tested for antigelling
activities. It was envisioned that these agents might bind via hydrophobic bonding to …

For over 20 years, the pathogenesis of sickling and of its clinical manifestations has
intrigued hematologists and molecular biologists. A series of observations has unraveled …

We have measured the solubility, and the rates of homogeneous and heterogeneous
nucleation on sickle hemoglobin (HbSβ6 Glu→ Val) additionally modified by site-directed …

Sickle cell disease (SCD) is an inherited disorder caused by a point mutation in the β-globin
gene leading to the formation of hemoglobin S (HbS). The polymerization of deoxygenated …

Getting out of a sticky situation | Science Translational Medicine news careers commentary
Journals Science Science brought to you byGoogle Indexer Log in science science advances …

Candidate drugs to counter intracellular polymerization of deoxygenated sickle hemoglobin
(Hb S) continue to represent a promising approach to mitigating the primary cause of the …

Nitrogen mustards inhibit gelling and red cell sickling by covalently binding hemoglobin S.
82His seems to be one of the modified sites and probably the one responsible for the …

Background: Hypoxia-induced sickle hemoglobin (HbS) polymerization in sickle red blood
cells (sRBCs) is the root cause of the symptoms and complications in sickle cell disease …