High-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non–small-cell lung cancer: Long-term results of a …

FM Kong, RK Ten Haken, MJ Schipper… - International Journal of …, 2005 - Elsevier
Purpose: To determine whether high-dose radiation leads to improved outcomes in patients
with non–small-cell lung cancer (NSCLC). Methods and Materials: This analysis included …

Dose escalation in non–small-cell lung cancer using three-dimensional conformal radiation therapy: Update of a phase I trial

JA Hayman, MK Martel, RK Ten Haken… - Journal of clinical …, 2001 - ascopubs.org
PURPOSE: High-dose radiation may improve outcomes in non–small-cell lung cancer
(NSCLC). By using three-dimensional conformal radiation therapy and limiting the target …

Higher biologically effective dose of radiotherapy is associated with improved outcomes for locally advanced non–small cell lung carcinoma treated with …

M Machtay, K Bae, B Movsas, R Paulus… - International Journal of …, 2012 - Elsevier
PURPOSE: Patients treated with chemoradiotherapy for locally advanced non–small-cell
lung carcinoma (LA-NSCLC) were analyzed for local-regional failure (LRF) and overall …

The benefit of treatment intensification is age and histology-dependent in patients with locally advanced non-small cell lung cancer (NSCLC): a quality-adjusted …

B Movsas, C Scott, W Sause, R Byhardt… - International Journal of …, 1999 - Elsevier
Purpose: Currently, chemoradiation treatment strategies in locally advanced NSCLC are
essentially the same irrespective of tumor histology or patient age. The purpose of this study …

Long-term results of high-dose conformal radiotherapy for patients with medically inoperable T1–3N0 non–small-cell lung cancer: Is low incidence of regional failure …

M Chen, JA Hayman, RK Ten Haken, D Tatro… - International Journal of …, 2006 - Elsevier
Purpose: To report the results of high-dose conformal irradiation and examine incidental
nodal irradiation and nodal failure in patients with inoperable early-stage non–small-cell …

Improved local control with higher doses of radiation in large-volume stage III non–small-cell lung cancer

R Rengan, KE Rosenzweig, E Venkatraman… - International Journal of …, 2004 - Elsevier
PURPOSE: It has been suggested that larger tumor volume is associated with poor survival
in patients with non–small-cell lung cancer (NSCLC). We investigated whether high-dose …

Comparison of outcomes for patients with medically inoperable Stage I non–small-cell lung cancer treated with two-dimensional vs. three-dimensional radiotherapy

LC Fang, R Komaki, P Allen, T Guerrero… - International Journal of …, 2006 - Elsevier
Purpose: This retrospective analysis was performed to assess the outcomes of three-
dimensional (3D) conformal radiotherapy and two-dimensional (2D) planning. Methods and …

Final toxicity results of a radiation-dose escalation study in patients with non–small-cell lung cancer (NSCLC): Predictors for radiation pneumonitis and fibrosis

FM Kong, JA Hayman, KA Griffith… - International Journal of …, 2006 - Elsevier
Purpose: We aimed to report the final toxicity results on a radiation-dose escalation trial
designed to test a hypothesis that very high doses of radiation could be safely administered …

A review of radiation dose escalation trials for non-small cell lung cancer within the Radiation Therapy Oncology Group

J Bradley - Seminars in oncology, 2005 - Elsevier
Chemotherapy and radiation therapy (RT) is the therapy of choice for patients with locally
advanced, inoperable non-small cell lung cancer (with an expected 4-year survival rate of …

Induction and concurrent chemotherapy with high-dose thoracic conformal radiation therapy in unresectable stage IIIA and IIIB non–small-cell lung cancer: A dose …

MA Socinski, DE Morris, JS Halle, DT Moore… - Journal of clinical …, 2004 - ascopubs.org
Purpose Local control rates at conventional radiotherapy doses (60 to 66 Gy) are poor in
stage III non–small-cell lung cancer (NSCLC). Dose escalation using three-dimensional …