SIRT1 Is Downregulated in Gastric Cancer and Leads to G1-phase Arrest via NF-κB/Cyclin D1 Signaling
Q Yang, B Wang, W Gao, S Huang, Z Liu, W Li… - Molecular cancer …, 2013 - AACR
Abstract Sirtuin 1 (SIRT1) is a class III histone/protein deacetylase, and its activation status
has been well documented to have physiologic benefits in human health. However, the …
has been well documented to have physiologic benefits in human health. However, the …
Trending topics of SIRT1 in tumorigenicity
LM Garcia-Peterson, X Li - Biochimica et Biophysica Acta (BBA)-General …, 2021 - Elsevier
Background Carcinogenesis is governed by a series of genetic alterations and epigenetic
changes that lead to aberrant patterns in neoplastic cells. Sirtuin-1 (SIRT1), an NAD+ …
changes that lead to aberrant patterns in neoplastic cells. Sirtuin-1 (SIRT1), an NAD+ …
JNK‐mediated Ser27 phosphorylation and stabilization of SIRT1 promote growth and progression of colon cancer through deacetylation‐dependent activation of Snail
Sirtuin 1 (SIRT1), an NAD+‐dependent histone/protein deacetylase, has multifaceted
functions in various biological events such as inflammation, aging, and energy metabolism …
functions in various biological events such as inflammation, aging, and energy metabolism …
Overexpression of SIRT4 inhibits the proliferation of gastric cancer cells through cell cycle arrest
Y Hu, J Lin, Y Lin, X Chen, G Zhu… - Oncology …, 2019 - spandidos-publications.com
The sirtuins (SIRTs) are a family of nicotinamide-adenine dinucleotide (NAD)+‑dependent
protein deacetylases. SIRT4 is a mitochondrial NAD+‑dependent adenosine diphsophate …
protein deacetylases. SIRT4 is a mitochondrial NAD+‑dependent adenosine diphsophate …
The clinical significance of SIRT2 in malignancies: a tumor suppressor or an oncogene?
L Zhang, S Kim, X Ren - Frontiers in Oncology, 2020 - frontiersin.org
Sirtuin 2 (SIRT2) is a member of the sirtuin protein family. It is a Class III histone deacetylase
(HDACs) and predominantly localized to the cytosol. SIRT2 deacetylates histones and a …
(HDACs) and predominantly localized to the cytosol. SIRT2 deacetylates histones and a …
Sirtuin 1 and oral cancer
The sirtuins (SIRTs) are a family of highly conserved histone deacetylases (HDACs)
consisting of seven members (SIRT1‑SIRT7). Over the past few decades, SIRT1 has been …
consisting of seven members (SIRT1‑SIRT7). Over the past few decades, SIRT1 has been …
Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma
L Lv, Z Shen, J Zhang, H Zhang, J Dong, Y Yan, F Liu… - Medical oncology, 2014 - Springer
Abstract Sirtuin 1 (SIRT1) has been reported to have diverse roles in various biological
processes through deacetylation of histone and nonhistone proteins. However, the …
processes through deacetylation of histone and nonhistone proteins. However, the …
Sirtuin1-p53: a potential axis for cancer therapy
J Yin, X Lu, M Hou, T Cao, Z Tian - Biochemical pharmacology, 2023 - Elsevier
Abstract Sirtuin1 (SIRT1) is a conserved nicotinamide adenine dinucleotide (NAD+)-
dependent histone deacetylase that plays key roles in a range of cellular events, including …
dependent histone deacetylase that plays key roles in a range of cellular events, including …
Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer
B Yang, X Fu, L Shao, Y Ding, D Zeng - Biochemical and biophysical …, 2014 - Elsevier
SIRT3 is a NAD+-dependent histone deacetylaseand and plays a critical role in various
human carcinomas. However, its precise role in the pathogenesis of gastric cancer (GC) is …
human carcinomas. However, its precise role in the pathogenesis of gastric cancer (GC) is …