Abstract Sirtuin 1 (SIRT1) is a class III histone/protein deacetylase, and its activation status
has been well documented to have physiologic benefits in human health. However, the …

Background Carcinogenesis is governed by a series of genetic alterations and epigenetic
changes that lead to aberrant patterns in neoplastic cells. Sirtuin-1 (SIRT1), an NAD+ …

Sirtuin 1 (SIRT1), an NAD+‐dependent histone/protein deacetylase, has multifaceted
functions in various biological events such as inflammation, aging, and energy metabolism …

The sirtuins (SIRTs) are a family of nicotinamide-adenine dinucleotide (NAD)+‑dependent
protein deacetylases. SIRT4 is a mitochondrial NAD+‑dependent adenosine diphsophate …

Sirtuin 2 (SIRT2) is a member of the sirtuin protein family. It is a Class III histone deacetylase
(HDACs) and predominantly localized to the cytosol. SIRT2 deacetylates histones and a …

The sirtuin family has emerged as important regulators of diverse physiological and
pathological events, including life-span extension, neurodegeneration, age-related …

The sirtuins (SIRTs) are a family of highly conserved histone deacetylases (HDACs)
consisting of seven members (SIRT1‑SIRT7). Over the past few decades, SIRT1 has been …

Abstract Sirtuin 1 (SIRT1) has been reported to have diverse roles in various biological
processes through deacetylation of histone and nonhistone proteins. However, the …

Abstract Sirtuin1 (SIRT1) is a conserved nicotinamide adenine dinucleotide (NAD+)-
dependent histone deacetylase that plays key roles in a range of cellular events, including …

SIRT3 is a NAD+-dependent histone deacetylaseand and plays a critical role in various
human carcinomas. However, its precise role in the pathogenesis of gastric cancer (GC) is …