[图书][B] Iodothyronine deiodinases: structure-function analysis and their role in the regulation of thyroid hormone levels

F Wassen - 2005 - repub.eur.nl
Thyroid hormone is important for energy metabolism, the metabolism of nutrients, inorganic
ion fluxes and thermogenesis. Thyroid hormone is also essential for stimulation of growth …

Molecular basis for the substrate selectivity of cat type I iodothyronine deiodinase

GGJM Kuiper, F Wassen, W Klootwijk… - …, 2003 - academic.oup.com
The type I iodothyronine deiodinase (D1) catalyzes the activation of T4 to T3 as well as the
degradation of T3 (rT3) and sulfated iodothyronines. A comparison of the catalytic activities …

Iodothyronine deiodinase structure and function: from ascidians to humans.

VM Darras, SL Van Herck - The Journal of endocrinology, 2012 - europepmc.org
Iodothyronine deiodinases are important mediators of thyroid hormone (TH) action. They are
present in tissues throughout the body where they catalyse 3, 5, 3'-triiodothyronine (T (3)) …

Structure-activity relationships for thyroid hormone deiodination by mammalian type I iodothyronine deiodinases

N Toyoda, E Kaptein, MJ Berry, JW Harney… - …, 1997 - academic.oup.com
The bioactivity of thyroid hormone is determined to a large extent by the monodeiodination
of the prohormone T4 by the hepatic selenoenzyme type I iodothyronine deiodinase (ID1), ie …

[PDF][PDF] THEMATIC REVIEW Deiodinases: the balance of thyroid hormone Type 1 iodothyronine deiodinase in human physiology and disease

AL Maia, IM Goemann, ELS Meyer… - Journal of …, 2011 - academia.edu
Thyroid hormone is essential for the normal function of virtually all tissues. The
iodothyronine deiodinases catalyze the removal of an iodine residue from the pro-hormone …

Defining the roles of the iodothyronine deiodinases: current concepts and challenges

DL St. Germain, VA Galton, A Hernandez - Endocrinology, 2009 - academic.oup.com
As is typical of other hormone systems, the actions of the thyroid hormones (TH) differ from
tissue to tissue depending upon a number of variables. In addition to varying expression …

Deiodinases and their intricate role in thyroid hormone homeostasis

C Luongo, M Dentice, D Salvatore - Nature Reviews Endocrinology, 2019 - nature.com
The deiodinase family of enzymes mediates the activation and inactivation of thyroid
hormone. The role of these enzymes in the regulation of the systemic concentrations of …

Type 1 iodothyronine deiodinase in human physiology and disease

AL Maia, IM Goemann, ELS Meyer… - Journal of …, 2011 - cir.nii.ac.jp
抄録< jats: p> Thyroid hormone is essential for the normal function of virtually all tissues. The
iodothyronine deiodinases catalyze the removal of an iodine residue from the pro-hormone …

[图书][B] Thyroid Hormone MetabolismMolecular Biology and Alternate Pathways

SY Wu, TJ Visser - 1994 - books.google.com
This book gathers some of the most talented and well-informed experts in the field, who not
only summarize the recent breakthroughs and new findings, but also shed light on future …

Modulation of type 2 iodothyronine deiodinase activity in rat thyroid gland

PC Lisboa, AP Cabanelas, FH Curty… - Hormone and …, 2007 - thieme-connect.com
& The majority of biological responses to thyroid hormones require the enzymatic
conversion of thyroxine (T4) to triiodothyronine (T3), the bioactive hormone. Two distinct …