Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C
BACKGROUND & AIMS: Mathematical modeling of hepatitis C virus (HCV) kinetics indicated
that cellular immune responses contribute to interferon (IFN)-induced clearance of HCV. We …
that cellular immune responses contribute to interferon (IFN)-induced clearance of HCV. We …
Activation of natural killer cells during acute infection with hepatitis C virus
B Amadei, S Urbani, A Cazaly, P Fisicaro, A Zerbini… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Natural killer (NK) cells are essential early after infection, not only
for viral containment but also for timely and efficient induction of adaptive responses. An …
for viral containment but also for timely and efficient induction of adaptive responses. An …
[HTML][HTML] Natural killer cells in hepatitis C: Current progress
JC Yoon, CM Yang, Y Song, JM Lee - World journal of …, 2016 - ncbi.nlm.nih.gov
Patients infected with the hepatitis C virus (HCV) are characterized by a high incidence of
chronic infection, which results in chronic hepatitis, liver cirrhosis, and hepatocellular …
chronic infection, which results in chronic hepatitis, liver cirrhosis, and hepatocellular …
Successful interferon-free therapy of chronic hepatitis C virus infection normalizes natural killer cell function
E Serti, X Chepa-Lotrea, YJ Kim, M Keane, N Fryzek… - Gastroenterology, 2015 - Elsevier
Background & Aims Chronic hepatitis C virus infection activates an intrahepatic immune
response, leading to increased expression of interferon (IFN)-stimulated genes and …
response, leading to increased expression of interferon (IFN)-stimulated genes and …
Natural killer cells in viral hepatitis: facts and controversies
MU Mondelli, S Varchetta… - European journal of …, 2010 - Wiley Online Library
Eur J Clin Invest 2010; 40 (9): 851–863 Abstract Background Hepatitis B virus (HBV) and
hepatitis C virus (HCV) are major human hepatotropic pathogens responsible for a large …
hepatitis C virus (HCV) are major human hepatotropic pathogens responsible for a large …
Natural killer cells: multifaceted players with key roles in hepatitis C immunity
L Golden‐Mason, HR Rosen - Immunological reviews, 2013 - Wiley Online Library
Natural killer cells (NK s) are involved in every stage of hepatitis C viral (HCV) infection, from
protection against HCV acquisition and resolution in the acute phase to treatment‐induced …
protection against HCV acquisition and resolution in the acute phase to treatment‐induced …
[HTML][HTML] Natural killer cells in viral hepatitis
B Rehermann - Cellular and molecular gastroenterology and …, 2015 - Elsevier
Natural killer (NK) cells are traditionally regarded as first-line effectors of the innate immune
response, but they also have a distinct role in chronic infection. Here, we review the role of …
response, but they also have a distinct role in chronic infection. Here, we review the role of …
Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C
J Nattermann, G Feldmann, G Ahlenstiel, B Langhans… - Gut, 2006 - gut.bmj.com
Introduction: Impaired activity of natural killer (NK) cells has been proposed as a mechanism
contributing to viral persistence in hepatitis C virus (HCV) infection. As the function of NK …
contributing to viral persistence in hepatitis C virus (HCV) infection. As the function of NK …
The paradox of NKp46+ natural killer cells: drivers of severe hepatitis C virus-induced pathology but in-vivo resistance to interferon α treatment
Objective There is evidence that natural killer (NK) cells help control persistent viral
infections including hepatitis C virus (HCV). The phenotype and function of blood and …
infections including hepatitis C virus (HCV). The phenotype and function of blood and …
Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa–dependent manner
G Ahlenstiel, RH Titerence, C Koh, B Edlich, JJ Feld… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Patients with chronic hepatitis C virus (HCV) infection display great
variability in disease activity and progression. Although virus-specific adaptive immune …
variability in disease activity and progression. Although virus-specific adaptive immune …
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