Nitroglycerin (glycerol trinitrate, GTN) induces headache in migraineurs, an effect that has
been used both diagnostically and in the study of the pathophysiology of this neurovascular …

The molecular mechanisms of migraine pain have not yet been clarified. Monoamine and
the peptide neurotransmitters involved in neurogenic inflammation do not cause significant …

Migraine is a disease for which there is still no defined pathophysiological etiology and few
translational models. The organic nitrate nitroglycerin has been in use as an experimental …

The association between the clinical use of nitroglycerin (NTG) and headache has led to the
examination of NTG as a model trigger for migraine and related headache disorders, both in …

It has previously been shown that in migraine sufferers infusion of glyceryl trinitrate (GTN)
and histamine causes an immediate headache during the infusion and a genuine migraine …

Systemic administration of nitroglycerin (NTG), a nitric oxide (NO) donor, in migraineurs
triggers after several hours an attack of which the precise mechanisms are unknown. We …

When administered to migraine patients, nitroglycerin induces a spontaneous-like migraine
attack, with a latency of several hours. Nitroglycerin acts directly and/or indirectly on the …

Experimental “vascular” headache in humans may be used in characterizing new migraine
drugs. The effects of sumatriptan on nitroglycerin‐(NTG)‐induced headache and arterial …

Previous studies suggest that nitric oxide NO) is involved in headaches induced by iv
infusion of the vasodilator and NO donor glyceryl trinitrat (GTN) in healthy subjects …

Migraine stands as one of the most disabling neurological conditions worldwide. It is a
disorder of great challenge to study given its heterogeneous representation, cyclic nature …