Biomechanical stimuli derived from the extracellular matrix (ECM) extremely tune stem cell
fate through 3D and spatiotemporal changes in vivo. The matrix stiffness is a crucial factor …

Bone marrow-derived multipotent stem and stromal cells (MSCs) are likely candidates for
cell-based therapies for various conditions including skeletal disease. Advancement of …

Stem cell behaviors are regulated by multiple microenvironmental cues. As an external
signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate …

Engineered living microtissues such as cellular spheroids and organoids have enormous
potential for the study and regeneration of tissues and organs. Microtissues are typically …

Lipid‐coated microbubbles, clinically approved as contrast enhancing agents for ultrasound
imaging, are investigated for the first time for their possible applications in bone tissue …

Bone formation and resorption are sensitive to both external loads arising from gravitational
loading as well to internal loads generated by muscular activity. The question as to which of …

Both fluid shear stress and matrix stiffness are implicated in bone metabolism and functional
adaptation, but the synergistic action of these mechanical cues on the biological behaviors …

Stimuli‐responsive materials enabling the behavior of the cells that reside within them to be
controlled are vital for the development of instructive tissue scaffolds for tissue engineering …

Ultrasound, or the application of acoustic energy, is a minimally invasive technique that has
been used in diagnostic, surgical, imaging, and therapeutic applications. Low-intensity …

Although only a few stem cell-based therapies are currently available to patients, stem cells
hold tremendous regenerative potential, and several exciting clinical applications are on the …