Neurosphere formation is an independent predictor of clinical outcome in malignant glioma
DR Laks, M Masterman-Smith, K Visnyei… - Stem …, 2009 - academic.oup.com
Renewable neurosphere formation in culture is a defining characteristic of certain brain
tumor initiating cells. This retrospective study was designed to assess the relationship …
tumor initiating cells. This retrospective study was designed to assess the relationship …
Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system
H Karlsson, M Fryknäs, R Larsson, P Nygren - Experimental cell research, 2012 - Elsevier
Clinically relevant in vitro methods are needed to identify new cancer drugs for solid tumors.
We report on a new 3-D spheroid cell culture system aimed to mimic the properties of solid …
We report on a new 3-D spheroid cell culture system aimed to mimic the properties of solid …
[HTML][HTML] Comparative analysis of tumor spheroid generation techniques for differential in vitro drug toxicity
Multicellular tumor spheroids are powerful in vitro models to perform preclinical
chemosensitivity assays. We compare different methodologies to generate tumor spheroids …
chemosensitivity assays. We compare different methodologies to generate tumor spheroids …
A 3D printed hanging drop dripper for tumor spheroids analysis without recovery
L Zhao, J Xiu, Y Liu, T Zhang, W Pan, X Zheng… - Scientific reports, 2019 - nature.com
Compared with traditional monolayer cell culture, the three-dimensional tumor spheroid has
emerged as an essential in vitro model for cancer research due to the recapitulation of the …
emerged as an essential in vitro model for cancer research due to the recapitulation of the …
Media additives to promote spheroid circularity and compactness in hanging drop platform
BM Leung, SC Lesher-Perez, T Matsuoka… - Biomaterials …, 2015 - pubs.rsc.org
Three-dimensional spheroid cultures have become increasingly popular as drug screening
platforms, especially with the advent of different high throughput spheroid forming …
platforms, especially with the advent of different high throughput spheroid forming …
Emulsion technologies for multicellular tumour spheroid radiation assays
KS McMillan, AG McCluskey, A Sorensen, M Boyd… - Analyst, 2016 - pubs.rsc.org
A major limitation with current in vitro technologies for testing anti-cancer therapies at the pre-
clinical level is the use of 2D cell culture models which provide a poor reflection of the …
clinical level is the use of 2D cell culture models which provide a poor reflection of the …
Gradient-sized control of tumor spheroids on a single chip
Multicellular tumor spheroids are attracting more attention as a physiologically relevant in
vitro tumor model for biomedical research. The size of spheroids is one of the critical …
vitro tumor model for biomedical research. The size of spheroids is one of the critical …
[HTML][HTML] Glioblastoma cell line-derived spheres in serum‑containing medium versus serum-free medium: A comparison of cancer stem cell properties
X Hong, K Chedid, SN Kalkanis - … journal of oncology, 2012 - spandidos-publications.com
In addition to the primary culturing of cancer stem cells (CSCs) from tumor tissues, CSCs are
found in established tumor cell lines. However, it is unclear how culture conditions affect …
found in established tumor cell lines. However, it is unclear how culture conditions affect …
Application of 3D cultured multicellular spheroid tumor models in tumor-targeted drug delivery system research
BW Huang, JQ Gao - Journal of controlled release, 2018 - Elsevier
Tumor-targeted drug delivery systems are promising for their advantages in enhanced tumor
accumulation and reduced toxicity towards normal organs. However, few nanomedicines …
accumulation and reduced toxicity towards normal organs. However, few nanomedicines …
Facile one step formation and screening of tumor spheroids using droplet‐microarray platform
Tumor spheroids or microtumors are important 3D in vitro tumor models that closely
resemble a tumor's in vivo “microenvironment” compared to 2D cell culture. Microtumors are …
resemble a tumor's in vivo “microenvironment” compared to 2D cell culture. Microtumors are …