Compared with traditional monolayer cell culture, the three-dimensional tumor spheroid has
emerged as an essential in vitro model for cancer research due to the recapitulation of the …

A major limitation with current in vitro technologies for testing anti-cancer therapies at the pre-
clinical level is the use of 2D cell culture models which provide a poor reflection of the …

Three-dimensional spheroid cultures have become increasingly popular as drug screening
platforms, especially with the advent of different high throughput spheroid forming …

Multicellular tumor spheroids are attracting more attention as a physiologically relevant in
vitro tumor model for biomedical research. The size of spheroids is one of the critical …

In addition to the primary culturing of cancer stem cells (CSCs) from tumor tissues, CSCs are
found in established tumor cell lines. However, it is unclear how culture conditions affect …

The in vitro self-assembly of multicellular spheroids generates highly organized structures in
which the three-dimensional structure and differentiated function frequently mimic that of in …

Clinically relevant in vitro methods are needed to identify new cancer drugs for solid tumors.
We report on a new 3-D spheroid cell culture system aimed to mimic the properties of solid …

Targeted drug delivery systems, especially those that use nanoparticles, have been the
focus of research into cancer therapy during the last decade, to improve the bioavailability …

Tumor spheroids or microtumors are important 3D in vitro tumor models that closely
resemble a tumor's in vivo “microenvironment” compared to 2D cell culture. Microtumors are …

Biomaterial-based tissue culture platforms have emerged as useful tools to mimic in vivo
physiological microenvironments in experimental cell biology and clinical studies. We …