Superantigens: structure-function relationships

MD Baker, KR Acharya - International Journal of Medical Microbiology, 2004 - Elsevier
Superantigens are a class of highly potent immuno-stimulatory molecules produced by
Staphylococcus aureus and Streptococcus pyogenes. These toxins possess the unique …

Structure and function of streptococcal and staphylococcal superantigens in septic shock

J Bannan, K Visvanathan, JB Zabriskie - Infectious disease clinics of North …, 1999 - Elsevier
The pyrogenic exotoxins of group A streptococci (SPEs) and the enterotoxins of
Staphylococcus aureus (SEs) constitute a family of structurally related toxins that also share …

Staphylococcal superantigens: pyrogenic toxins induce toxic shock

T Krakauer - Toxins, 2019 - mdpi.com
Staphylococcal enterotoxin B (SEB) and related superantigenic toxins produced by
Staphylococcus aureus are potent activators of the immune system. These protein toxins …

Molecular structure of staphylococcus and streptococcus superantigens

PM Schlievert, GA Bohach, DH Ohlendorf… - Journal of clinical …, 1995 - Springer
Staphylococcus aureus and streptococci, notably those belonging to group A, make up a
large family of true exotoxins referred to as pyrogenic toxin superantigens. These toxins …

Role of superantigens in human disease

PM Schlievert - Journal of Infectious Diseases, 1993 - academic.oup.com
Superantigens include bacterial products (mainly ofstreptococci and staphylococci) that
stimulate T cells to proliferate nonspecifically through interaction with class II major …

Immune response to staphylococcal superantigens

T Krakauer - Immunologic research, 1999 - Springer
Staphylococcal exotoxins, staphylococcal enterotoxins AE (SEA-SEE), and toxic shock
syndrome toxin-1 (TSST-1) are potent activators of the immune system and cause a variety …

A structural and functional comparison of staphylococcal enterotoxins A and C2 reveals remarkable similarity and dissimilarity

EM Schad, AC Papageorgiou, LA Svensson… - Journal of molecular …, 1997 - Elsevier
Staphylococcal enterotoxins and toxic shock syndrome toxin-1 are known as superantigens
due to their ability to activate a large number of T-cells by crosslinking the major …

Staphylococcal and streptococcal superantigen exotoxins

AR Spaulding, W Salgado-Pabón… - Clinical microbiology …, 2013 - Am Soc Microbiol
This review begins with a discussion of the large family of Staphylococcus aureus and beta-
hemolytic streptococcal pyrogenic toxin T lymphocyte superantigens from structural and …

Superantigens: a tool to gain new insight into cellular immunity

S Florquin, L Aaldering - Research in immunology, 1997 - Elsevier
The majority of superantigens are products of microorganisms which have powerful
immunostimulatory and immunosuppressive properties and play a key role in human …

Staphylococcal and streptococcal superantigens: molecular, biological and clinical aspects

JE Alouf, H Müller-Alouf - International journal of medical microbiology, 2003 - Elsevier
Superantigens (SAgs) include a class of certain bacterial and viral proteins exhibiting highly
potent lymphocyte-transforming (mitogenic) activity towards human and or other mammalian …