Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life
C Kriegebaum, NN Song, L Gutknecht, Y Huang… - Neurochemistry …, 2010 - Elsevier
Several lines of evidence implicate a dysregulation of tryptophan hydroxylase (TPH)-
dependent serotonin (5-HT) synthesis in emotional behaviour and stress, and point to its …
dependent serotonin (5-HT) synthesis in emotional behaviour and stress, and point to its …
[HTML][HTML] Impacts of Brain Serotonin Deficiency following Tph2 Inactivation on Development and Raphe Neuron Serotonergic Specification
L Gutknecht, N Araragi, S Merker, J Waider… - 2012 - journals.plos.org
Brain serotonin (5-HT) is implicated in a wide range of functions from basic physiological
mechanisms to complex behaviors, including neuropsychiatric conditions, as well as in …
mechanisms to complex behaviors, including neuropsychiatric conditions, as well as in …
Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice
L Gutknecht, C Kriegebaum, J Waider, A Schmitt… - European …, 2009 - Elsevier
Dysregulation of tryptophan hydroxylase (TPH)-dependent serotonin (5-HT) synthesis, has
been implicated in various neuropsychiatric disorders, although the differential expression …
been implicated in various neuropsychiatric disorders, although the differential expression …
[HTML][HTML] Generation of a Tph2 Conditional Knockout Mouse Line for Time- and Tissue-Specific Depletion of Brain Serotonin
B Pelosi, M Pratelli, S Migliarini, G Pacini… - PLoS …, 2015 - journals.plos.org
Serotonin has been gaining increasing attention during the last two decades due to the dual
function of this monoamine as key regulator during critical developmental events and as …
function of this monoamine as key regulator during critical developmental events and as …
Targeted manipulation of brain serotonin: RNAi-mediated knockdown of tryptophan hydroxylase 2 in rats
S Matthes, V Mosienko, E Popova… - ACS Chemical …, 2019 - ACS Publications
Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of the biogenic
monoamine serotonin (5-hydroxytryptamine, 5-HT). Two existing TPH isoforms are …
monoamine serotonin (5-hydroxytryptamine, 5-HT). Two existing TPH isoforms are …
Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels
K Nakamura, Y Sugawara, K Sawabe… - Journal of …, 2006 - Soc Neuroscience
Serotonin [5-hydroxytryptamine (5-HT)] is a major therapeutic target of psychiatric disorders.
Tryptophan hydroxylase (TPH) catalyzes the rate-limiting reaction in the biosynthesis of 5 …
Tryptophan hydroxylase (TPH) catalyzes the rate-limiting reaction in the biosynthesis of 5 …
[HTML][HTML] Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants
KV Savelieva, S Zhao, VM Pogorelov, I Rajan, Q Yang… - PloS one, 2008 - journals.plos.org
The neurotransmitter serotonin (5-HT) plays an important role in both the peripheral and
central nervous systems. The biosynthesis of serotonin is regulated by two rate-limiting …
central nervous systems. The biosynthesis of serotonin is regulated by two rate-limiting …
Life without brain serotonin: reevaluation of serotonin function with mice deficient in brain serotonin synthesis
V Mosienko, D Beis, M Pasqualetti, J Waider… - Behavioural brain …, 2015 - Elsevier
Tryptophan hydroxylase (TPH) is a rate limiting enzyme in the synthesis of serotonin (5-HT),
a monoamine which works as an autacoid in the periphery and as a neurotransmitter in the …
a monoamine which works as an autacoid in the periphery and as a neurotransmitter in the …
Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice
L Gutknecht, J Waider, S Kraft, C Kriegebaum… - Journal of neural …, 2008 - Springer
The relative contribution of the two tryptophan hydroxylase (TPH) isoforms, TPH1 and TPH2,
to brain serotonergic system function is controversial. To investigate the respective role of …
to brain serotonergic system function is controversial. To investigate the respective role of …
Tryptophan hydroxylase 2 (TPH 2) in a neuronal cell line: modulation by cell differentiation and NRSF/rest activity
MT Gentile, Y Nawa, G Lunardi, T Florio… - Journal of …, 2012 - Wiley Online Library
Abstract Serotonin (5‐HT) is a neurotransmitter involved in many aspects of the neuronal
function. The synthesis of 5‐HT is initiated by the hydroxylation of tryptophan, catalyzed by …
function. The synthesis of 5‐HT is initiated by the hydroxylation of tryptophan, catalyzed by …