Exercise mitigates flow recirculation and activates metabolic transducer SCD1 to catalyze vascular protective metabolites
Exercise promotes pulsatile shear stress in the arterial circulation and ameliorates
cardiometabolic diseases. However, exercise-mediated metabolic transducers for vascular …
cardiometabolic diseases. However, exercise-mediated metabolic transducers for vascular …
Exercise rescues gene pathways involved in vascular expansion and promotes functional angiogenesis in subcutaneous white adipose tissue
Exercise mitigates chronic diseases such as diabetes, cardiovascular diseases, and obesity;
however, the molecular mechanisms governing protection from these diseases are not …
however, the molecular mechanisms governing protection from these diseases are not …
Flow-responsive vascular endothelial growth factor receptor-protein kinase C isoform epsilon signaling mediates glycolytic metabolites for vascular repair
Aims: Hemodynamic shear stress participates in maintaining vascular redox status.
Elucidating flow-mediated endothelial metabolites enables us to discover metabolic …
Elucidating flow-mediated endothelial metabolites enables us to discover metabolic …
Elevated arterial shear rate increases indexes of endothelial cell autophagy and nitric oxide synthase activation in humans
SK Park, DT La Salle, J Cerbie… - American Journal …, 2019 - journals.physiology.org
Continuous laminar shear stress increases the process of autophagy, activates endothelial
nitric oxide (NO) synthase phosphorylation at serine 1177 (p-eNOSS1177), and generates …
nitric oxide (NO) synthase phosphorylation at serine 1177 (p-eNOSS1177), and generates …
Advances in exercise-induced vascular adaptation: mechanisms, models, and methods
H Sun, Y Zhang, L Shi - Frontiers in Bioengineering and …, 2024 - frontiersin.org
Insufficient physical activity poses a significant risk factor for cardiovascular diseases.
Exercise plays a crucial role in influencing the vascular system and is essential for …
Exercise plays a crucial role in influencing the vascular system and is essential for …
Atherosclerosis and flow: roles of epigenetic modulation in vascular endothelium
DY Lee, JJ Chiu - Journal of Biomedical Science, 2019 - Springer
Background Endothelial cell (EC) dysfunctions, including turnover enrichment, gap junction
disruption, inflammation, and oxidation, play vital roles in the initiation of vascular disorders …
disruption, inflammation, and oxidation, play vital roles in the initiation of vascular disorders …
Aerobic exercise training prevents perivascular adipose tissue-induced endothelial dysfunction in thoracic aorta of obese mice
AS Sousa, ACS Sponton, CB Trifone… - Frontiers in …, 2019 - frontiersin.org
Background: The mechanisms underlying the perivascular adipose tissue (PVAT)
dysfunction in obesity are closely related to inflammation and oxidative stress. The present …
dysfunction in obesity are closely related to inflammation and oxidative stress. The present …
Preclinical techniques to investigate exercise training in vascular pathophysiology
Atherosclerosis is a dynamic process starting with endothelial dysfunction and inflammation
and eventually leading to life-threatening arterial plaques. Exercise generally improves …
and eventually leading to life-threatening arterial plaques. Exercise generally improves …
Disturbed flow induces systemic changes in metabolites in mouse plasma: a metabolomics study using ApoE−/− mice with partial carotid ligation
Disturbed blood flow (d-flow) occurring in branched and curved arteries promotes
endothelial dysfunction and atherosclerosis, in part, by altering gene expression and …
endothelial dysfunction and atherosclerosis, in part, by altering gene expression and …
Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells
X Qin, J Tian, P Zhang, Y Fan, L Chen… - Cardiovascular …, 2007 - academic.oup.com
Objective: Laminar shear stress plays critical roles in vascular homeostasis and exerts
various metabolic effects on endothelial cells (ECs). Stearoyl-CoA desaturase-1 (SCD1) …
various metabolic effects on endothelial cells (ECs). Stearoyl-CoA desaturase-1 (SCD1) …