Comparative evaluation of recombinant protein production in different biofactories: the green perspective

M Merlin, E Gecchele, S Capaldi… - BioMed research …, 2014 - Wiley Online Library
In recent years, the production of recombinant pharmaceutical proteins in heterologous
systems has increased significantly. Most applications involve complex proteins and …

A comparative analysis of recombinant protein expression in different biofactories: bacteria, insect cells and plant systems

E Gecchele, M Merlin, A Brozzetti, A Falorni… - JoVE (Journal of …, 2015 - jove.com
Plant-based systems are considered a valuable platform for the production of recombinant
proteins as a result of their well-documented potential for the flexible, low-cost production of …

Plant‐made pharmaceuticals: Leading products and production platforms

M Paul, JKC Ma - Biotechnology and applied biochemistry, 2011 - Wiley Online Library
The number of approaches to recombinant protein production in plants is greater than ever
before. Development of these new and improved technologies as production platforms for …

[HTML][HTML] On the verge of the market–Plant factories for the automated and standardized production of biopharmaceuticals

JW Huebbers, JF Buyel - Biotechnology Advances, 2021 - Elsevier
The market for biopharmaceuticals is dominated by recombinant proteins and is driven
mainly by the development of vaccines and antibodies. Manufacturing predominantly relies …

Recombinant plant-derived pharmaceutical proteins: current technical and economic bottlenecks

M Sabalza, P Christou, T Capell - Biotechnology letters, 2014 - Springer
Molecular pharming is a cost-effective platform for the production of recombinant proteins in
plants. Although the biopharmaceutical industry still relies on a small number of …

Commercial aspects of pharmaceutical protein production in plants

R Fischer, S Schillberg, JF Buyel… - Current …, 2013 - ingentaconnect.com
Many different plant-based systems have been used to produce recombinant
pharmaceutical proteins but only a small number have made the leap from an experimental …

[HTML][HTML] Plant molecular farming: A viable platform for recombinant biopharmaceutical production

B Shanmugaraj, CJ I. Bulaon, W Phoolcharoen - Plants, 2020 - mdpi.com
The demand for recombinant proteins in terms of quality, quantity, and diversity is increasing
steadily, which is attracting global attention for the development of new recombinant protein …

Molecular farming of pharmaceutical proteins using plant suspension cell and tissue cultures

S Schillberg, N Raven, R Fischer… - Current …, 2013 - ingentaconnect.com
Plants have been used for more than 20 years to produce recombinant proteins but only
recently has the focus shifted away from proof-of-principle studies (ie is my protein …

Expression systems for the production of recombinant pharmaceuticals

R Sodoyer - BioDrugs, 2004 - Springer
The new generation of biological products are largely the result of genetic engineering. The
qualitative and quantitative demand for recombinant proteins is steadily increasing …

Process development strategies in plant molecular farming

JF Buyel - Current Pharmaceutical Biotechnology, 2015 - ingentaconnect.com
Protein-based biopharmaceuticals are often produced in mammalian cell cultures, which are
more expensive than microbial systems but capable of authentic post-translational …