[HTML][HTML] MicroRNA therapeutics: principles, expectations, and challenges

R Rupaimoole, HD Han, G Lopez-Berestein… - Chinese journal of …, 2011 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are a class of highly abundant non-coding RNA molecules that are
involved in several biological processes. Many miRNAs are often deregulated in several …

MicroRNAs: master regulators of drug resistance, stemness, and metastasis

U Raza, JD Zhang, Ö Şahin - Journal of molecular medicine, 2014 - Springer
Abstract MicroRNAs (miRNAs) are 20–22 nucleotides long small non-coding RNAs that
regulate gene expression post-transcriptionally. Last decade has witnessed emerging …

[HTML][HTML] Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry

P Wang, Y Zhou, AM Richards - Theranostics, 2021 - ncbi.nlm.nih.gov
The approval of the first small interfering RNA (siRNA) drug Patisiran by FDA in 2018 marks
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …

An overview of microRNAs

SM Hammond - Advanced drug delivery reviews, 2015 - Elsevier
The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in
molecular biology. There are now over 2000 miRNAs that have been discovered in humans …

MicroRNA as a potential therapeutic molecule in cancer

J Szczepanek, M Skorupa, A Tretyn - Cells, 2022 - mdpi.com
Small noncoding RNAs, as post-translational regulators of many target genes, are not only
markers of neoplastic disease initiation and progression, but also markers of response to …

RNAi-based therapeutics and novel RNA bioengineering technologies

GM Traber, AM Yu - Journal of Pharmacology and Experimental …, 2023 - ASPET
RNA interference (RNAi) provides researchers with a versatile means to modulate target
gene expression. The major forms of RNAi molecules, genome-derived microRNAs …

MicroRNA therapeutics

JA Broderick, PD Zamore - Gene therapy, 2011 - nature.com
MicroRNAs (miRNAs) provide new therapeutic targets for many diseases, while their myriad
roles in development and cellular processes make them fascinating to study. We still do not …

Therapeutic implication of miRNA in human disease

A Walayat, M Yang, D Xiao - Antisense therapy, 2018 - books.google.com
MicroRNAs (miRNAs) are a class of short non-coding RNA molecules that are involved in
development and diseases. Early studies are focusing on the miRNA profile as a biomarker …

MicroRNA delivery through nanoparticles

SWL Lee, C Paoletti, M Campisi, T Osaki… - Journal of Controlled …, 2019 - Elsevier
MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to
their central role in the etiology of major diseases. On the other hand, nanoparticle carriers …

Developing therapeutic microRNAs for cancer

AG Bader, D Brown, J Stoudemire, P Lammers - Gene therapy, 2011 - nature.com
Despite substantial progress in understanding the cancer-signaling network, effective
therapies remain scarce due to insufficient disruption of oncogenic pathways, drug …